{"created":"2023-05-15T14:48:38.575989+00:00","id":66639,"links":{},"metadata":{"_buckets":{"deposit":"add77d1f-cac3-4fe2-ad98-af89d04454bd"},"_deposit":{"created_by":1,"id":"66639","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"66639"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00066639","sets":["10:29"]},"author_link":["655359","655357","655358","655354","655356","655355","655352","655353"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2017-09-16","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【目的】活性酸素種(ROS)による生物影響評価を行うには、細胞内のような水相と油相が入り組んだ環境下での酸化還元(レドックス)状態変化の定量的評価法の開発が必要である。そこで、油水混合環境中で生じるROSの脂質への影響評価法の確立を試みた。\n【方法】50 µMの2,2-ジフェニル-1-ピクリルヒドラジル(DPPH)ラジカルを含有するリポソーム懸濁液を作製した。フェントン反応または過酸化水素のUV照射によって生じるヒドロキシルラジカル量と、脂質中のDPPHラジカルの消失を電子常磁性共鳴(EPR)法を用いて測定し、比較した。\n【結果】ヒドロキシルラジカルの増加に伴って膜中DPPHラジカルのシグナル強度は減少した。\n【考察】DPPHラジカル含有リポソームを用いることにより、レドックス状態の変化による脂質中DPPHラジカルの減衰を定量的に評価することが可能となった。今後、脂質ラジカルによる脂質中DPPHラジカルの減衰についても検討を行う。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第61回日本薬学会関東支部大会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"小川, 幸大"}],"nameIdentifiers":[{"nameIdentifier":"655352","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"関根（鈴木）, 絵美子"}],"nameIdentifiers":[{"nameIdentifier":"655353","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中西, 郁夫"}],"nameIdentifiers":[{"nameIdentifier":"655354","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松本, 謙一郎"}],"nameIdentifiers":[{"nameIdentifier":"655355","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小川 幸大","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"655356","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"関根 絵美子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"655357","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中西 郁夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"655358","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松本 謙一郎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"655359","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"油水混合環境中でのレドックス反応評価","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"油水混合環境中でのレドックス反応評価"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-03-09"},"publish_date":"2018-03-09","publish_status":"0","recid":"66639","relation_version_is_last":true,"title":["油水混合環境中でのレドックス反応評価"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:46:39.041477+00:00"}