{"created":"2023-05-15T14:48:35.597872+00:00","id":66572,"links":{},"metadata":{"_buckets":{"deposit":"23e0f688-083c-4fc0-994a-dc2067b7e905"},"_deposit":{"created_by":1,"id":"66572","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"66572"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00066572","sets":["10:29"]},"author_link":["654830","654832","654836","654831","654833","654826","654828","654834","654827","654829","654837","654835"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2017-10-05","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【目的】腹腔内にがん病巣が広がる腹膜播種は、予後不良因子であることが知られ、治療法の開発が求められている。一方、放射性標識抗体を腹腔内に投与する放射免疫療法（ここでは腹腔内放射免疫療法とよぶ）は、腹膜播種に対する有望な治療法として期待されている。本研究では、実用性の高い放射性核種である64Cuを用いた腹腔内放射免疫療法の有用性を64Cu標識抗EGFR抗体（セツキシマブ）を用い検討した。【方法・結果】ヒト大腸がんHCT116-RFP安定発現細胞をマウス腹腔内注射し、腹膜播種モデルを作成した。治療実験に先立ち、64Cu標識セツキシマブの体内分布を検討したところ、静脈内投与に比べ、腹腔内投与では、腹膜播種に対する放射能集積が早期(30分)に高くなること、正常臓器への集積は低いことが明らかとなった。次に、64Cu標識セツキシマブを腹腔内投与する治療実験を行ったところ、副作用なく、生存が有意に延長した。【結論】64Cu腹腔内放射免疫療法は、大腸がん腹膜播種に対し、有用な治療法となる可能性が示唆された。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第57回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"吉井, 幸恵"}],"nameIdentifiers":[{"nameIdentifier":"654826","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉本, 光喜"}],"nameIdentifiers":[{"nameIdentifier":"654827","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松本, 博樹"}],"nameIdentifiers":[{"nameIdentifier":"654828","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張, 明栄"}],"nameIdentifiers":[{"nameIdentifier":"654829","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須尭, 綾"}],"nameIdentifiers":[{"nameIdentifier":"654830","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻, 厚至"}],"nameIdentifiers":[{"nameIdentifier":"654831","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"東, 達也"}],"nameIdentifiers":[{"nameIdentifier":"654832","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉井 幸恵","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"654833","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"654834","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須尭 綾","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"654835","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻 厚至","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"654836","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"東 達也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"654837","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"腹膜播種に対する64Cu標識セツキシマブを用いた腹腔内放射免疫療法の有用性の検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"腹膜播種に対する64Cu標識セツキシマブを用いた腹腔内放射免疫療法の有用性の検討"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-12-28"},"publish_date":"2017-12-28","publish_status":"0","recid":"66572","relation_version_is_last":true,"title":["腹膜播種に対する64Cu標識セツキシマブを用いた腹腔内放射免疫療法の有用性の検討"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:47:25.673181+00:00"}