{"created":"2023-05-15T14:48:33.501359+00:00","id":66525,"links":{},"metadata":{"_buckets":{"deposit":"66e9bf4f-0e49-4c3e-8c73-24453c5f215b"},"_deposit":{"created_by":1,"id":"66525","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"66525"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00066525","sets":["10:29"]},"author_link":["654415","654406","654407","654411","654412","654414","654416","654410","654418","654409","654413","654408","654417"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2017-11-07","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The mechanisms underlying bi-directional signaling involved in radiation-induced bystander effect (RIBE) between irradiated carcinoma cells and their surrounding non-irradiated normal cells is relevant to radiation cancer therapy. Using the SPICE-NIRS microbeam, we delivered 500 protons to A549-GFP lung carcinoma cells, stably expressing H2B-GFP, that were co-cultured with normal WI-38 cells. The level of γ-H2AX, a marker for DNA double-strand breaks (DSB), was subsequently measured up to 24 h post irradiation in both targeted and bystander cells. As a result, gap junction intercellular communication (GJIC) inhibition attenuated DSB repair in targeted A549-GFP cells, and RIBE was suppressed in bystander WI-38 cells but not in distant A549-GFP cells. This suggested that GJIC plays a two-way role either propagating DNA damage effect between carcinoma to normal cells, or reversing the bystander signaling, also called a “rescue effect” from bystander cells to irradiated cells, in order to enhance the DSB repair in targeted cells. ","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"MICROS 2017 17th International Symposium on Microdosimetry","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kobayashi, Alisa"}],"nameIdentifiers":[{"nameIdentifier":"654406","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Autsavapromporn, Narongchai"}],"nameIdentifiers":[{"nameIdentifier":"654407","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ahbrizal, Farizal Tengku Ahmad Tengku"}],"nameIdentifiers":[{"nameIdentifier":"654408","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Oikawa, Masakazu"}],"nameIdentifiers":[{"nameIdentifier":"654409","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Homma-Takeda, Shino"}],"nameIdentifiers":[{"nameIdentifier":"654410","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Furusawa, Yoshiya"}],"nameIdentifiers":[{"nameIdentifier":"654411","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Wang, Jun"}],"nameIdentifiers":[{"nameIdentifier":"654412","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Konishi, Teruaki"}],"nameIdentifiers":[{"nameIdentifier":"654413","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小林 亜利紗","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"654414","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"及川 将一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"654415","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"武田 志乃","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"654416","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古澤 佳也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"654417","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小西 輝昭","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"654418","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Bystander WI-38 normal lung fibroblast cells modulate DNA double-strand break repair in microbeam-targeted A549 cells through gap junction intercellular communication","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Bystander WI-38 normal lung fibroblast cells modulate DNA double-strand break repair in microbeam-targeted A549 cells through gap junction intercellular communication"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-11-22"},"publish_date":"2017-11-22","publish_status":"0","recid":"66525","relation_version_is_last":true,"title":["Bystander WI-38 normal lung fibroblast cells modulate DNA double-strand break repair in microbeam-targeted A549 cells through gap junction intercellular communication"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:47:59.051264+00:00"}