{"created":"2023-05-15T14:48:31.545706+00:00","id":66482,"links":{},"metadata":{"_buckets":{"deposit":"e2728b29-909e-47f3-95dd-e2958a0f588e"},"_deposit":{"created_by":1,"id":"66482","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"66482"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00066482","sets":["10:29"]},"author_link":["653971","653978","653986","653973","653974","653975","653976","653972","653980","653984","653985","653983","653977","653982","653981","653979"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2017-10-07","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":" \n【目的】モノアシルグリセロールリパーゼ（MAGL）は、痛みに関連するカンナビノイド受容体１（CB1）の活性を制御している酵素である。本研究では、当研究グループで開発されたMAGLに選択的なPETプローブ[11C]SAR127303を用いて、定量解析を試みた。\n【方法】[11C]SAR127303のPET定量解析は、two tissue compartment modelにより行い、MAGLの定量値は、Ki値（Ki=(K1*k3)/(k2+k3)）を用いた。算出したKi値は、in vitroオートラジオグラフィ（ARG）の放射能集積と相関関係を確認した。\n【結果】Ki値（mL/cm3/min）は、帯状回で最も高い値（0.17）を示し、次いで線条体（0.16）、小脳（0.14）、視床下部（0.10）となった。また、ARGの放射能集積も同様の結果が得られ、高い相関を示した。\n【結論】[11C]SAR127303を用いたPET定量解析により、MAGLの脳内密度を反映した値を測定できた。\n","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第57回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"山崎, 友照"}],"nameIdentifiers":[{"nameIdentifier":"653971","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"森, 若菜"}],"nameIdentifiers":[{"nameIdentifier":"653972","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張, 一鼎"}],"nameIdentifiers":[{"nameIdentifier":"653973","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"脇坂, 秀克"}],"nameIdentifiers":[{"nameIdentifier":"653974","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤永, 雅之"}],"nameIdentifiers":[{"nameIdentifier":"653975","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"栗原, 雄祐"}],"nameIdentifiers":[{"nameIdentifier":"653976","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"念垣, 信樹"}],"nameIdentifiers":[{"nameIdentifier":"653977","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張, 明栄"}],"nameIdentifiers":[{"nameIdentifier":"653978","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山崎 友照","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"653979","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"森 若菜","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"653980","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 一鼎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"653981","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"脇坂 秀克","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"653982","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤永 雅之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"653983","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"栗原 雄祐","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"653984","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"念垣 信樹","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"653985","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"653986","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"[11C]SAR127303を用いたモノアシルグリセロールリパーゼ（MAGL）PET定量解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"[11C]SAR127303を用いたモノアシルグリセロールリパーゼ（MAGL）PET定量解析"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-10"},"publish_date":"2017-10-10","publish_status":"0","recid":"66482","relation_version_is_last":true,"title":["[11C]SAR127303を用いたモノアシルグリセロールリパーゼ（MAGL）PET定量解析"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:48:28.485567+00:00"}