{"created":"2023-05-15T14:48:31.500993+00:00","id":66481,"links":{},"metadata":{"_buckets":{"deposit":"ebd88d6a-b181-4a56-a608-c80f6ebb89fe"},"_deposit":{"created_by":1,"id":"66481","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"66481"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00066481","sets":["10:29"]},"author_link":["653967","653961","653970","653964","653965","653968","653969","653962","653963","653966"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2017-10-06","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"電子豊富もしくは活性化されていないベンゼン環への18F原子導入は18F標識技術の大きな問題となっている。近年、この問題を解決するため、ヨードニウム塩や有機ホウ素化合物を前駆体とする18F化反応が開発されている。本研究では、新たに18F化の前駆体として注目されているスピロ環ヨードニウムイリドを用い、その汎用性を検討するため様々な18F-リガンドの合成を行うことを目的とした。標識合成を行うためヨードベンゼン誘導体を合成後、酸化反応、スピロ環骨格の導入を経て前駆体となるイリド体を合成した。次に、4級アンモニウム塩のアセトニトリル水溶液で18F-をQMAより溶出、乾燥後アセトニトリル、イリド前駆体の溶解性が低い場合にはDMF中、120℃10分でヨードニウムイリドのフッ素化反応を行った。フッ素化反応はいずれのリガンド合成においても35±15%、放射化学純度も> 98%で得ることに成功した。現在、更に汎用性を広げるために合成検討中で、詳細については本会にて報告する予定である。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第57回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"藤永, 雅之"}],"nameIdentifiers":[{"nameIdentifier":"653961","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"熊田, 勝志"}],"nameIdentifiers":[{"nameIdentifier":"653962","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"森, 若菜"}],"nameIdentifiers":[{"nameIdentifier":"653963","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小川, 政直"}],"nameIdentifiers":[{"nameIdentifier":"653964","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張, 明栄"}],"nameIdentifiers":[{"nameIdentifier":"653965","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤永 雅之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"653966","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"熊田 勝志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"653967","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"森 若菜","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"653968","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小川 政直","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"653969","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"653970","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"スピロ環ヨードニウムイリドを用いた18F-リガンドの合成検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"スピロ環ヨードニウムイリドを用いた18F-リガンドの合成検討"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-10"},"publish_date":"2017-10-10","publish_status":"0","recid":"66481","relation_version_is_last":true,"title":["スピロ環ヨードニウムイリドを用いた18F-リガンドの合成検討"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:48:29.156403+00:00"}