{"created":"2023-05-15T14:48:29.492523+00:00","id":66436,"links":{},"metadata":{"_buckets":{"deposit":"55a1c14e-4021-445b-933d-9aa23cd588bd"},"_deposit":{"created_by":1,"id":"66436","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"66436"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00066436","sets":["10:29"]},"author_link":["653650","653652","653653","653651"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2017-09-16","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In carbon-ion radiotherapy, single-beam delivery each day in alternate directions has been commonly practiced for efficient operation, taking advantage of the Bragg peak and the relative biological effectiveness (RBE) for uniform dose conformation to a tumor.\nThese treatments are generally fractionated and their plans are evaluated with total RBE-weighted dose, which is however deficient in relevance to the biological effect.\nIn this study, we reformulate the biologically effective dose (BED) to normalize the dose-fractionation and cell-repopulation effects as well as the RBE of treating radiation, based on the inactivation of a reference cell line by a reference carbon-ion radiation.\nThe BED distribution virtually represents the biological effect of a treatment regardless of radiation modality or fractionation scheme.\nWe applied the BED formulation to simplistic model treatments and to a preclinical survey for hypofractionation based on an actual prostate-cancer treatment with carbon ions. \nThe proposed formulation was demonstrated to be practical and implicative.\nFor the prostate-cancer treatment in 12 fractions, the distributions of BED and of RBE-weighted dose were very similar. \nWith hypofractionation, while the RBE-weighted-dose distribution varied significantly, the BED distribution was nearly invariant, implying that the carbon-ion radiotherapy would be virtually insensitive to fractionation.\nHowever, treatment evaluation with such simplistic biological dose is intrinsically limited and must be complemented in practice by clinical experience and biology experiment.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第114回日本医学物理学会学術大会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kanematsu, Nobuyuki"}],"nameIdentifiers":[{"nameIdentifier":"653650","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Inaniwa, Taku"}],"nameIdentifiers":[{"nameIdentifier":"653651","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"兼松 伸幸","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"653652","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"稲庭 拓","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"653653","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Biological dose representation for carbon-ion radiotherapy of unconventional fractionation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Biological dose representation for carbon-ion radiotherapy of unconventional fractionation"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-09-19"},"publish_date":"2017-09-19","publish_status":"0","recid":"66436","relation_version_is_last":true,"title":["Biological dose representation for carbon-ion radiotherapy of unconventional fractionation"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:48:58.268574+00:00"}