@misc{oai:repo.qst.go.jp:00066014, author = {李, 惠子 and 諸越, 幸恵 and 長谷川, 純崇 and 李 惠子 and 諸越 幸恵 and 長谷川 純崇}, month = {Nov}, note = {Peritoneal metastasis of gastric cancer (PMGC) has extremely poor prognosis, however, there is no effective therapeutics has been established. About 20% of GC is reported as HER2-overexpressed (HER2+), and trastuzumab, a humanized anti-HER2 monoclonal antibody, has been used for the treatment for HER2+ PMGC. Radioimmunotherapy (RIT) has huge advantages in targeting metastatic cancer and the application of alpha-emitter into RIT is getting higher attention. Astatine 211 (211At) is one of the useful alpha-emitter. In this study, we investigated the cell cytotoxicity and therapeutic efficacy of RIT with 211At-trastuzumab against of HER2+ PMGC both in vitro and in vivo. We will discuss the possibility of alpha-RIT with 211At-trastuzumab as a new effective therapeutics for HER2+ PMGC., 第56回日本核医学会学術集会}, title = {HER2高発現胃がん腹膜播種に対するα線放出核種211Atを用いた放射免疫療法}, year = {2016} }