{"created":"2023-05-15T14:48:02.177681+00:00","id":65835,"links":{},"metadata":{"_buckets":{"deposit":"08e84d91-82c1-4295-ab9d-6843d3a0d11f"},"_deposit":{"created_by":1,"id":"65835","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"65835"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00065835","sets":["10:29"]},"author_link":["648559","648560","648561","648565","648564","648557","648558","648563","648562","648566"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2015-04-21","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Artemis and XRCC4 are members of core factors for non-homologous end joining (NHEJ), a primary repair pathway of DNA double-strand breaks (DSBs). To clarify the participation of Artemis and XRCC4 in DNA damage response (DDR) to high-LET ionizing irradiation (IR), we examined the cellular responses of isogenic human cell lines deficient for these factors (Artemis-/- and XRCC4-/- cells) and a parental HCT116 cells to carbon ion-beams. Substantial increase in sensitivity of Artemis-/- and XRCC4-/- cells to carbon ion-beams as compared to HCT116 cells demonstrated participation of Artemis and XRCC4 in DDR to high-LET IR. Remarkably, the values for relative biological effectiveness (RBE) of carbon ion-beams to X-rays on killing of the Artemis-/-, XRCC4-/- and HCT116 cells appeared to be 2.7, 2.8 and 3.0, respectively. This result is inconsistent with previous reports showing that high-LET IR is much effective as compared to low-LET IR on killing of most cell lines, but not on killing of NHEJ-deficient cells including Ku70, Ku80 and DNA-PKcs mutant lines. To address this discrepancy, we have started to examine induction and repair of DSBs in the Artemis-/-, XRCC4-/- and HCT116 cells following irradiation of carbon ion-beams by gamma-H2AX nuclear foci analyses.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"H26年度HIMAC共同利用研究成果発表会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"勝部, 孝則"}],"nameIdentifiers":[{"nameIdentifier":"648557","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Qiang, LIU"}],"nameIdentifiers":[{"nameIdentifier":"648558","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"DU, Liqing"}],"nameIdentifiers":[{"nameIdentifier":"648559","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yan, WANG"}],"nameIdentifiers":[{"nameIdentifier":"648560","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Chang, XU"}],"nameIdentifiers":[{"nameIdentifier":"648561","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"二宮, 康晴"}],"nameIdentifiers":[{"nameIdentifier":"648562","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"王, 冰"}],"nameIdentifiers":[{"nameIdentifier":"648563","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"勝部 孝則","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"648564","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"二宮 康晴","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"648565","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"王 冰","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"648566","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"重粒子線に対する細胞応答におけるDNA損傷応答関連因子の機能に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"重粒子線に対する細胞応答におけるDNA損傷応答関連因子の機能に関する研究"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-12-18"},"publish_date":"2015-12-18","publish_status":"0","recid":"65835","relation_version_is_last":true,"title":["重粒子線に対する細胞応答におけるDNA損傷応答関連因子の機能に関する研究"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:55:44.472436+00:00"}