{"created":"2023-05-15T14:48:01.373981+00:00","id":65817,"links":{},"metadata":{"_buckets":{"deposit":"3f364626-ddde-4a6a-a188-5154e7775e23"},"_deposit":{"created_by":1,"id":"65817","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"65817"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00065817","sets":["10:29"]},"author_link":["648332","648328","648327","648336","648322","648321","648324","648341","648320","648337","648339","648338","648333","648334","648325","648335","648340","648323","648326","648329","648331","648330"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2015-11-05","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"代謝型グルタミン酸受容体5(mGluR5)は、神経変性疾患に関連の深い神経受容体として注目されている。本研究では、テトラゾール骨格を含むmGluR5を標的とした新規PETプローブの開発を目指し、候補化合物を合成し、評価を行った。ラット脳ホモジネートを用いた結合試験において、候補化合物中のメチル体5は最も高いmGluR5への親和性(Ki)を示した。化合物5の標識合成は、ブロモ体原料から[11C]CH3Iを用いた高速メチル化法で行い、合成時間約35分、放射化学的純度99%以上，放射化学的収率10±4％([11C]CO2から、EOS)で得られた。ラット脳切片を用いて[11C]5のオートラジオグラフィを行ったところ、mGluR5に選択的な結合が見られた。続いて、ラットを用いてPET撮像を行ったところmGluR5の高密度領域である線条体に、高い放射能の取り込みが見られた。以上の結果から，[11C]5はmGluR5の有用なPETリガンドであることが示唆された。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第55回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"下田, 陽子"}],"nameIdentifiers":[{"nameIdentifier":"648320","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤永, 雅之"}],"nameIdentifiers":[{"nameIdentifier":"648321","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山崎, 友照"}],"nameIdentifiers":[{"nameIdentifier":"648322","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"熊田, 勝志"}],"nameIdentifiers":[{"nameIdentifier":"648323","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"由井, 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