{"created":"2023-05-15T14:48:01.153799+00:00","id":65812,"links":{},"metadata":{"_buckets":{"deposit":"2d61cb14-2ecb-4abe-9471-e3889f59f0d7"},"_deposit":{"created_by":1,"id":"65812","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"65812"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00065812","sets":["10:29"]},"author_link":["648286","648282","648288","648277","648284","648279","648285","648283","648287","648291","648278","648280","648281","648290","648276","648289"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2015-11-05","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"グループI代謝型グルタミン酸受容体（mGluR1とmGluR5） は，神経変性疾患に関わる分子として注目されている．本研究では，パーキンソン病 (PD) の病因遺伝子であるA53T変異alpha-synuclein (ASN) を過剰発現させたラット(A53T-Tg)を用いて，ドーパミン神経の変性に伴ったmGluR1及びmGluR5の変化をPETによりモニタリングした．\nA53T-Tgラットは6月齢から行動量が減少する個体が現れ始め，16月齢でほぼ全個体で野生型に比べ有意に減少した．mGluR1 ([11C]ITDM), mGluR5 ([11C]ABP688), 及びドーパミン神経 ([18F]FE-PE2I) に対する選択的な放射性リガンドを用いて行ったPETイメージングで，mGluR1のbinding potential (BPND)は，A53T-Tgラットで月齢と共に減少し，行動量の減少と高い相関を示し，また，ドーパミン神経に対するBPNDの減少に対しても比較的高い相関を示した．対照的に，mGluR5のBPNDは，月齢による変化は見られず，PD病態との相関も見られなかった． \n　本研究により， mGluR5ではなく，mGluR1がASNの蓄積による神経変性に関与していることが示された．","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第55回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"山崎, 友照"}],"nameIdentifiers":[{"nameIdentifier":"648276","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤永, 雅之"}],"nameIdentifiers":[{"nameIdentifier":"648277","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"由井, 譲二"}],"nameIdentifiers":[{"nameIdentifier":"648278","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"脇坂, 秀克"}],"nameIdentifiers":[{"nameIdentifier":"648279","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"河村, 和紀"}],"nameIdentifiers":[{"nameIdentifier":"648280","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"念垣, 信樹"}],"nameIdentifiers":[{"nameIdentifier":"648281","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"潮見, 聡"}],"nameIdentifiers":[{"nameIdentifier":"648282","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張, 明栄"}],"nameIdentifiers":[{"nameIdentifier":"648283","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山崎 友照","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"648284","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤永 雅之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"648285","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"由井 譲二","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"648286","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"脇坂 秀克","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"648287","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"河村 和紀","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"648288","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"念垣 信樹","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"648289","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"潮見 聡","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"648290","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"648291","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"パーキンソン病モデルラットにおけるグループI代謝型グルタミン酸受容体を標的としたPETイメージング","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"パーキンソン病モデルラットにおけるグループI代謝型グルタミン酸受容体を標的としたPETイメージング"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-11-19"},"publish_date":"2015-11-19","publish_status":"0","recid":"65812","relation_version_is_last":true,"title":["パーキンソン病モデルラットにおけるグループI代謝型グルタミン酸受容体を標的としたPETイメージング"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:55:59.087232+00:00"}