{"created":"2023-05-15T14:48:01.109068+00:00","id":65811,"links":{},"metadata":{"_buckets":{"deposit":"ef731df0-d910-4084-8220-dbaf05496a8b"},"_deposit":{"created_by":1,"id":"65811","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"65811"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00065811","sets":["10:29"]},"author_link":["648267","648260","648265","648256","648275","648263","648271","648272","648259","648274","648270","648273","648268","648261","648269","648257","648262","648258","648266","648264"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2015-11-05","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"代謝型グルタミン酸受容体4型(mGlu4)は主に脳内の線条体、海馬、視床、小脳に局在化しており、パーキンソン病に対し潜在的な治療効果が期待される受容体である。mGlu4受容体のイメージングによりパーキンソン病におけるmGlu4の詳細な機能や役割を解明できると考えられるが、これまでに利用可能なイメージング剤は開発されていない。今回、我々は、mGlu4に選択的なリガンドであるADX88178に着目し、[11C]ADX88178を合成するため、ピリミジン環の4位への11CH3基導入検討ならびに動物評価を行った。前駆体及び標品は市販品を用いて5-7段階で合成した。 [11C]CH3Iを用いたピリミジン骨格への11CH3基導入はPd2(dba)3,P(o-tol)3,CuCl,K2CO3存在下では未反応の[11C]CH3Iが多く見られた。塩基としてCsFを用い、すべての試薬をあらかじめ混合したうえで、[11C]CH3Iを捕集することで効率よく11C-メチル化が進行し、続く脱ベンジル化までの放射化学的収率は15%であった。 [11C]ADX88178において、ラット脳切片を用いたin vitro ARGでは、mGlu4が存在する部位でわずかな結合能を示した。詳細については本会にて発表する。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第55回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"藤永, 雅之"}],"nameIdentifiers":[{"nameIdentifier":"648256","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山崎, 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勝志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"648272","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"下田 陽子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"648273","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"河村 和紀","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"648274","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"648275","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference 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