{"created":"2023-05-15T14:48:00.974493+00:00","id":65808,"links":{},"metadata":{"_buckets":{"deposit":"e02f3b0e-2497-41f6-be23-0eb6f9953fc2"},"_deposit":{"created_by":1,"id":"65808","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"65808"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00065808","sets":["10:29"]},"author_link":["648244","648237","648235","648241","648246","648240","648236","648230","648247","648231","648238","648232","648242","648248","648239","648243","648249","648234","648245","648233"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2015-11-05","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"イミダゾリンI2受容体（I2R）は摂食中枢である視床下部に多く存在し、摂食機能との関連が示されているが、その役割は十分に解明されていない。我々は、I2Rイメージングを摂食機能の診断と治療薬の評価に繋げるために、I2R選択的PET用リガンド[11C]BU99008（Ki=1.4 nM）を超高比放射能化することにより、微小な脳部位である視床下部や微細な変化についてイメージングできる可能性をPET測定により評価した。超高比放射能[11C]BU99008はSingle-pass 法により製造された[11C]ヨウ化メチルから合成し、正常もしくは肥満ラットを用いて脳PET測定を行った。[11C]BU99008は実験に適した収量と放射化学的純度で得られ、比放射能は5400～16600 TBq/mmol（合成終了時）で得られた。PET測定では、視床下部への高集積が見られ、高親和性I2RリガンドBU224前処理により投与後30～60分間の放射能集積が86%も阻害され、高い特異的結合が示された。超高比放射能[11C]BU99008を用いたPET測定は、微小な視床下部をイメージングできる有用なPET用リガンドであると考えられる。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第55回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"河村, 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政直"}],"nameIdentifiers":[{"nameIdentifier":"648238","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張, 明栄"}],"nameIdentifiers":[{"nameIdentifier":"648239","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"河村 和紀","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"648240","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"下田 陽子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"648241","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"由井 譲二","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"648242","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 一鼎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"648243","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山崎 友照","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"648244","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"脇坂 秀克","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"648245","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤永 雅之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"648246","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"熊田 勝志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"648247","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小川 政直","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"648248","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"648249","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference 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