{"created":"2023-05-15T14:48:00.385626+00:00","id":65795,"links":{},"metadata":{"_buckets":{"deposit":"fb0bfc65-eef8-44cd-bb5e-7aee21cfc37e"},"_deposit":{"created_by":1,"id":"65795","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"65795"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00065795","sets":["10:29"]},"author_link":["648126","648122","648124","648127","648128","648119","648129","648121","648125","648120","648123"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2015-11-05","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"生体数学モデルを用いたアミロイドPETイメージングにおける臨床SUVR予測\n○荒川悠真1, 志田原美保1,2, Ying Hwey Nai 2, 古本祥三2, 関千江3, 岡村信行4, 田代学4, 工藤幸司5, 谷内一彦4, 権田幸祐1, 渡部浩司2(1.東北大・医保, 2.東北大・サイクロ, 3.放医研・分イメ, 4.東北大・医, 5.東北大・加齢研)\n\\n【目的】: アミロイドPET薬剤のヒト脳内動態を予測しSUVRを算出する手法を提案した。【方法】:標的領域と参照領域のTACを入力関数と動態変数(K1、k2、BPND)から算出する。K1、k2、BPNDは薬剤の脂溶性(logP)、体積(Vx)、組織中遊離濃度(fND)、血漿中遊離濃度(fp)、解離定数(KD)、Aβ蛋白の密度(Bavail)から数学モデルを用い予測した。logPはMlogPとClogPを, fNDとfpはWan et al, 2007, Summerfield et al., 2006. Guo et al., 2009の各文献値から算出したlogP対fNDとfND対fpの回帰式を用い算出した。提案手法の最適化のため、6通りの計算条件で予測した6つのアミロイドPET薬剤のSUVR値と臨床SUVR値を比較した。【結果】:2つの計算条件で、予測と臨床SUVRの間で良い相関(R2=0.70)がみられた。【結論】:提案手法が他アミロイドPET薬剤のSUVR予測へ適応できる可能性が示唆された。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第55回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"荒川, 悠馬"}],"nameIdentifiers":[{"nameIdentifier":"648119","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"志田原, 美保"}],"nameIdentifiers":[{"nameIdentifier":"648120","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hwey, Nai Ying"}],"nameIdentifiers":[{"nameIdentifier":"648121","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古本, 祥三"}],"nameIdentifiers":[{"nameIdentifier":"648122","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"関, 千江"}],"nameIdentifiers":[{"nameIdentifier":"648123","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岡村 信行"}],"nameIdentifiers":[{"nameIdentifier":"648124","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田代, 学"}],"nameIdentifiers":[{"nameIdentifier":"648125","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"谷内, 一彦"}],"nameIdentifiers":[{"nameIdentifier":"648126","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"権田, 幸祐"}],"nameIdentifiers":[{"nameIdentifier":"648127","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"渡部, 浩司"}],"nameIdentifiers":[{"nameIdentifier":"648128","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"関 千江","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"648129","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":" 生体数学モデルを用いたアミロイドPETイメージングにおける臨床SUVR予測","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":" 生体数学モデルを用いたアミロイドPETイメージングにおける臨床SUVR予測"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-11-10"},"publish_date":"2015-11-10","publish_status":"0","recid":"65795","relation_version_is_last":true,"title":[" 生体数学モデルを用いたアミロイドPETイメージングにおける臨床SUVR予測"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:56:10.610151+00:00"}