{"created":"2023-05-15T14:48:00.294894+00:00","id":65793,"links":{},"metadata":{"_buckets":{"deposit":"ccf59866-2d00-4ecc-b525-eb0ac155f7cc"},"_deposit":{"created_by":1,"id":"65793","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"65793"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00065793","sets":["10:29"]},"author_link":["648089","648103","648094","648095","648090","648104","648106","648098","648105","648092","648107","648102","648108","648093","648097","648096","648109","648110","648091","648100","648099","648101"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2015-11-05","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"アルツハイマー病をはじめとした認知症において、タウの沈着は重要な病理学的特徴である。その診断や新規治療の評価において、タウ病変の定量的画像化が可能になれば有用である。11C-PBB3 PETにおいて、その放射性代謝物の脳移行を考慮し、タウ病変を定量的画像化する方法を確立した。【方法】7人のアルツハイマー病患者と7人の健常者に対し、11C-PBB3 PETを行い、同時に動脈採血と代謝物分析を行った。定量解析は、脳内放射性代謝物を考慮したdual-input modelと参照領域法 (MRTMO)、standardized uptake value ratio (SUVR)で行った。【結果】MRTMOで求めたbinding potential (BPND)はdual-input modelで求めたBPNDと一致した (r2 = 1.00)。SUVR-1はMRTMO BPNDとよく相関した (r2 ＞ 0.97)。【結論】dual-input model BPND、MRTMO BPND、SUVR-1はお互いによく一致しており、放射性代謝物の脳移行にもかかわらず、11C-PBB3のタウへの結合を定量可能である。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第55回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"木村, 泰之"}],"nameIdentifiers":[{"nameIdentifier":"648089","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"市瀬, 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真人","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"648110","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"11C-PBB3を用いたタウ病変のPET定量解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"11C-PBB3を用いたタウ病変のPET定量解析"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-11-09"},"publish_date":"2015-11-09","publish_status":"0","recid":"65793","relation_version_is_last":true,"title":["11C-PBB3を用いたタウ病変のPET定量解析"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:56:12.006058+00:00"}