{"created":"2023-05-15T14:47:59.125583+00:00","id":65767,"links":{},"metadata":{"_buckets":{"deposit":"cea1ff35-e5a1-4f2f-b44e-5d9f4e4566a1"},"_deposit":{"created_by":1,"id":"65767","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"65767"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00065767","sets":["10:29"]},"author_link":["647840","647844","647826","647845","647841","647842","647834","647832","647825","647836","647828","647830","647827","647833","647839","647831","647829","647843","647838","647846","647837","647835"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2014-11-07","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":" \n【目的】P糖タンパク（Pgp）及び乳がん耐性タンパク（BCRP）は，血液脳関門の中核的な役割を担っている薬剤排出トランスポーターである．本研究では，これらの排出能をPgp及びBCRPの基質である[11C]elacridarを用いてPETにより定量することを目的とした．\n【方法】[11C]Elacridarの解析方法を決定するため，過剰量の阻害剤(10 mg/kg Tariquidar)によりPgp及びBCRPの機能を失活させたラット脳において，動態解析を行った．トランスポーターの排出能の指標となるk2パラメーターのPgp及びBCRPの機能依存性は，阻害剤を用いた容量反応試験により評価した．\n【結果】阻害剤を投与されたラット脳における[11C]elacridarの動態解析の結果，two-tissue compartment modelがPET定量解析に適していることが示された．コントロールラット脳におけるPET定量解析の結果，阻害剤投与ラットと比較して，K1，k3及びk4の速度パラメーターに有意差は見られなかったのに対し，k2値は10-15倍高くなった．さらに，阻害剤による容量反応試験の結果，k2パラメーターは阻害剤の投与量依存的な減少を示した．\n【結論】[11C]elacridar-PETは，Pgp及びBCRPによる薬剤排出能を定量できる有望なツールである。\n","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第54回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"山崎, 友照"}],"nameIdentifiers":[{"nameIdentifier":"647825","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"河村, 和紀"}],"nameIdentifiers":[{"nameIdentifier":"647826","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"由井, 譲二"}],"nameIdentifiers":[{"nameIdentifier":"647827","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"下田, 陽子"}],"nameIdentifiers":[{"nameIdentifier":"647828","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大矢, 智幸"}],"nameIdentifiers":[{"nameIdentifier":"647829","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"念垣, 信樹"}],"nameIdentifiers":[{"nameIdentifier":"647830","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"羽鳥, 晶子"}],"nameIdentifiers":[{"nameIdentifier":"647831","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤永, 雅之"}],"nameIdentifiers":[{"nameIdentifier":"647832","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"謝, 琳"}],"nameIdentifiers":[{"nameIdentifier":"647833","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"熊田, 勝志"}],"nameIdentifiers":[{"nameIdentifier":"647834","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張, 明栄"}],"nameIdentifiers":[{"nameIdentifier":"647835","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山崎 友照","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"647836","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"河村 和紀","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"647837","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"由井 譲二","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"647838","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"下田 陽子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"647839","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大矢 智幸","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"647840","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"念垣 信樹","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"647841","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"羽鳥 晶子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"647842","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤永 雅之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"647843","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"謝 琳","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"647844","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"熊田 勝志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"647845","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"647846","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"[11C]Elacridarを用いた薬剤排出トランスポーター機能のPET定量解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"[11C]Elacridarを用いた薬剤排出トランスポーター機能のPET定量解析"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-09-28"},"publish_date":"2015-09-28","publish_status":"0","recid":"65767","relation_version_is_last":true,"title":["[11C]Elacridarを用いた薬剤排出トランスポーター機能のPET定量解析"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:56:30.304650+00:00"}