{"created":"2023-05-15T14:47:58.987971+00:00","id":65764,"links":{},"metadata":{"_buckets":{"deposit":"cb23e4a3-e647-4dc7-812a-93314ca39ffc"},"_deposit":{"created_by":1,"id":"65764","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"65764"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00065764","sets":["10:29"]},"author_link":["647772","647768","647778","647779","647774","647766","647780","647767","647764","647763","647769","647770","647775","647765","647777","647771","647773","647776"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2014-11-06","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"代謝型グルタミン酸受容体1型(mGlu1)は正常脳内だけでなく、メラノーマなどの腫瘍でも高い密度で発現する事が知られている。我々は、メラノーマの診断や治療薬による効果の判定に有用なmGlu1のPETプローブとして[18F]FITMを開発している。本研究は脳移行性を抑えつつ、高い腫瘍特異性を持つPETプローブの開発を目的とした。まず、FITMのF原子をCl、Br及びIに変えた誘導体1-3を設計し、N-デスメチル体と[11C]CH3OTfの反応により[11C]1-3を合成した。次にmGlu1が過剰に発現するメラノーマ細胞B16F10をC57BL/6マウスに移植して作製した担癌マウスに対し、[11C]1-3による放射能分布試験とPET撮像を行った。その結果、分布試験では、[11C]1-3がB16F10腫瘍巣に高い集積を示した。特に[11C]3は投与後90分の放射能濃度が腫瘍で4.61%ID/g、脳で0.57%ID/gであった。また、腫瘍/脳の放射能比は[18F]-FITMの0.58に対し、[11C]1-3がそれぞれ1.04、1.73、8.03であった。さらに[11C]3を投与したPET画像では、腫瘍に顕著な集積が見られ、FITMの前投与によりその集積が大きく低下した。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第54回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"藤永, 雅之"}],"nameIdentifiers":[{"nameIdentifier":"647763","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"謝, 琳"}],"nameIdentifiers":[{"nameIdentifier":"647764","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山崎, 友照"}],"nameIdentifiers":[{"nameIdentifier":"647765","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"由井, 譲二"}],"nameIdentifiers":[{"nameIdentifier":"647766","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"熊田, 勝志"}],"nameIdentifiers":[{"nameIdentifier":"647767","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"下田, 陽子"}],"nameIdentifiers":[{"nameIdentifier":"647768","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"羽鳥, 晶子"}],"nameIdentifiers":[{"nameIdentifier":"647769","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"念垣, 信樹"}],"nameIdentifiers":[{"nameIdentifier":"647770","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張, 明栄"}],"nameIdentifiers":[{"nameIdentifier":"647771","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤永 雅之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"647772","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"謝 琳","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"647773","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山崎 友照","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"647774","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"由井 譲二","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"647775","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"熊田 勝志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"647776","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"下田 陽子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"647777","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"羽鳥 晶子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"647778","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"念垣 信樹","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"647779","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"647780","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"腫瘍に発現する代謝型グルタミン酸受容体1をターゲットとするPETプローブの開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"腫瘍に発現する代謝型グルタミン酸受容体1をターゲットとするPETプローブの開発"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-09-28"},"publish_date":"2015-09-28","publish_status":"0","recid":"65764","relation_version_is_last":true,"title":["腫瘍に発現する代謝型グルタミン酸受容体1をターゲットとするPETプローブの開発"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:56:32.402546+00:00"}