{"created":"2023-05-15T14:47:58.942946+00:00","id":65763,"links":{},"metadata":{"_buckets":{"deposit":"1ccca3b5-f3d4-4ce7-9306-9fa102ca7df8"},"_deposit":{"created_by":1,"id":"65763","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"65763"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00065763","sets":["10:29"]},"author_link":["647742","647753","647762","647761","647751","647741","647745","647749","647754","647759","647755","647752","647757","647756","647758","647760","647748","647750","647743","647747","647744","647746"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2014-11-08","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【目的】我々はヒスタミンH3受容体に結合する新規な2-[11C]メトキシピリジル基をもつPETプローブ(11C)TASP0410457:(1)の合成を[11C]CH3I法で行い、放射化学的収率（RCY）1.7 ± 0.3 % (EOS)で得る事に成功した。しかしながら、<B>1</B>を用いて広範囲な研究を行うには低収率であるため、我々は1の合成法の改善を試みた。【方法・結果】標識中間体に[11C]CH3OTf (2)、塩基として炭酸セシウム、溶媒としてDMFを用い、反応温度100度にて３分間の反応時間で製造を行ったところ、1のRCYは4.1±0.8 % (EOS)であった。さらに2を吹き込む際の温度を室温から100度に変え、反応時間なしで製造を行うとRCYが6.9±1.6 %、比放射能が133±72 GBq/μmol (n=17, EOS)となり、1のRCYを大幅に改善し、反応時間の短縮にも成功した。【結論】加熱方法を工夫することで1の収率向上が達成でき、かつ高い再現性がある方法を確立できた。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第54回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"破入, 正行"}],"nameIdentifiers":[{"nameIdentifier":"647741","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"武井, 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