{"created":"2023-05-15T14:47:58.898201+00:00","id":65762,"links":{},"metadata":{"_buckets":{"deposit":"5c6b5c4a-3698-44b9-ae55-d97a439bdf87"},"_deposit":{"created_by":1,"id":"65762","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"65762"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00065762","sets":["10:29"]},"author_link":["647738","647740","647733","647732","647735","647730","647731","647736","647737","647728","647729","647739","647734","647727"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2014-11-06","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【目的】収束超音波とマイクロバブルを用いた非侵襲的・局所的・一時的な血液脳関門（BBB）開放術は中枢神経への薬物送達手法として注目されている。本手法ではBBB開放を非侵襲的に評価する方法の確立が課題であり、PETが有効であると考えられる。これまで我々は [3-11C]AIBによるBBB評価の有用性について報告してきた。そこで本研究では [3-11C]AIB PETを用いた収束超音波-マイクロバブルによるBBB開放の評価を試みた。\n【方法】BBBの開放はマイクロバブル投与直後、超音波を照射することにより処置した。[3-11C]AIBは超音波照射後の経過時間を変えて投与した。\n【結果】PET撮像した結果、[3-11C]AIBの集積が超音波照射数時間後まで観測され、BBB開放を画像化できた。一方、長時間（5時間）経つとこの集積が確認できなかったことから、BBBの回復が示唆された。\n【結論】以上の結果から、[3-11C]AIB PETは薬物送達を目的とした収束超音波-マイクロバブルによるBBB開放の評価に有用であると示唆された。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第54回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"岡田, 真希"}],"nameIdentifiers":[{"nameIdentifier":"647727","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻, 厚至"}],"nameIdentifiers":[{"nameIdentifier":"647728","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"菊池, 達矢"}],"nameIdentifiers":[{"nameIdentifier":"647729","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"脇坂, 秀克"}],"nameIdentifiers":[{"nameIdentifier":"647730","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岡村, 敏充"}],"nameIdentifiers":[{"nameIdentifier":"647731","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"加藤, 孝一"}],"nameIdentifiers":[{"nameIdentifier":"647732","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張, 明栄"}],"nameIdentifiers":[{"nameIdentifier":"647733","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岡田 真希","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"647734","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻 厚至","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"647735","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"菊池 達矢","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"647736","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"脇坂 秀克","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"647737","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岡村 敏充","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"647738","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"加藤 孝一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"647739","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"647740","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"2-Amino-[3-11C]isobutyric acid PETを用いた収束超音波-マイクロバブルによる血液脳関門開放の評価","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"2-Amino-[3-11C]isobutyric acid PETを用いた収束超音波-マイクロバブルによる血液脳関門開放の評価"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-09-28"},"publish_date":"2015-09-28","publish_status":"0","recid":"65762","relation_version_is_last":true,"title":["2-Amino-[3-11C]isobutyric acid PETを用いた収束超音波-マイクロバブルによる血液脳関門開放の評価"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:56:34.216513+00:00"}