{"created":"2023-05-15T14:47:55.360267+00:00","id":65681,"links":{},"metadata":{"_buckets":{"deposit":"45ac864e-448b-4fd1-b494-90740919709b"},"_deposit":{"created_by":1,"id":"65681","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"65681"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00065681","sets":["10:29"]},"author_link":["647003","647001","647007","647004","647000","647005","647006","647002"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2015-05-29","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objectives: Introduction of carbonyl moiety into an aryl or heteroaryl group are powerful processes for the construction of valuable pharmacophore. However typical carbonylation reaction using [11C]O generally requires high pressure and high temperature conditions. Therefore, the development of convenient method for the [11C]carbonylation reaction is needed. Here we present the Pd(0)-mediated mild [11C]carbonylation reaction using [11C]O and boronic acid pinacol esters. Methods: The [11C]O, which prepared from [11C]O2, was reacted with aryl and heteroarylboronic acid pinacol esters in the presence of p-benzoquinone and triphenylphosphine in MeOH or DMF-MeOH (v/v =1:1) at 65 °C under atmospheric pressure for 5 min to give corresponding [11C]esters. Some of these [11C]esters were converted to corresponding [11C]amides by treatment with 25% ammonia solution 65 °C for 5 min. Scheme 1. Radiosynthesis of [carbonyl-11C]esters and [carbonyl-11C]amides\n\\nResults: Various aryl/heteroaryl boronates were converted to the corresponding [carbonyl-11C]esters with decay-corrected radiochemical yield in the range of 6-80%  \nConclusions:  \nAcknowledgeme","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"21st International Symposium on Radiopharmaceutical Sciences","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ishii, Hideki"}],"nameIdentifiers":[{"nameIdentifier":"647000","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Minegishi, Katsuyuki"}],"nameIdentifiers":[{"nameIdentifier":"647001","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nagatsu, Koutarou"}],"nameIdentifiers":[{"nameIdentifier":"647002","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Ming-Rong"}],"nameIdentifiers":[{"nameIdentifier":"647003","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"石井 英樹","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"647004","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"峯岸 克行","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"647005","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"永津 弘太郎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"647006","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"647007","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Pd(0)-mediated [11C]carbonylation of boronic acid pinacol esters with [11C]carbon monoxide and the facile conversion of [carbonyl-11C]esters to [carbonyl-11C]amides ","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Pd(0)-mediated [11C]carbonylation of boronic acid pinacol esters with [11C]carbon monoxide and the facile conversion of [carbonyl-11C]esters to [carbonyl-11C]amides "}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-06-17"},"publish_date":"2015-06-17","publish_status":"0","recid":"65681","relation_version_is_last":true,"title":["Pd(0)-mediated [11C]carbonylation of boronic acid pinacol esters with [11C]carbon monoxide and the facile conversion of [carbonyl-11C]esters to [carbonyl-11C]amides "],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:57:26.155019+00:00"}