@misc{oai:repo.qst.go.jp:00065681,
 author = {Ishii, Hideki and Minegishi, Katsuyuki and Nagatsu, Koutarou and Zhang, Ming-Rong and 石井 英樹 and 峯岸 克行 and 永津 弘太郎 and 張 明栄},
 month = {May},
 note = {Objectives: Introduction of carbonyl moiety into an aryl or heteroaryl group are powerful processes for the construction of valuable pharmacophore. However typical carbonylation reaction using [11C]O generally requires high pressure and high temperature conditions. Therefore, the development of convenient method for the [11C]carbonylation reaction is needed. Here we present the Pd(0)-mediated mild [11C]carbonylation reaction using [11C]O and boronic acid pinacol esters. Methods: The [11C]O, which prepared from [11C]O2, was reacted with aryl and heteroarylboronic acid pinacol esters in the presence of p-benzoquinone and triphenylphosphine in MeOH or DMF-MeOH (v/v =1:1) at 65 °C under atmospheric pressure for 5 min to give corresponding [11C]esters. Some of these [11C]esters were converted to corresponding [11C]amides by treatment with 25% ammonia solution 65 °C for 5 min. Scheme 1. Radiosynthesis of [carbonyl-11C]esters and [carbonyl-11C]amides
\nResults: Various aryl/heteroaryl boronates were converted to the corresponding [carbonyl-11C]esters with decay-corrected radiochemical yield in the range of 6-80%  
Conclusions:  
Acknowledgeme, 21st International Symposium on Radiopharmaceutical Sciences},
 title = {Pd(0)-mediated [11C]carbonylation of boronic acid pinacol esters with [11C]carbon monoxide and the facile conversion of [carbonyl-11C]esters to [carbonyl-11C]amides},
 year = {2015}
}