{"created":"2023-05-15T14:47:54.516286+00:00","id":65662,"links":{},"metadata":{"_buckets":{"deposit":"bbfaa697-00c2-4284-a68e-778056e5d0af"},"_deposit":{"created_by":1,"id":"65662","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"65662"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00065662","sets":["10:29"]},"author_link":["834378","834391","834382","834384","834393","834388","834387","834389","834381","834390","834380","834379","834386","834392","834377","834383","834385","834376"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2015-05-21","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"目的: Progressive supranuclear palsy (PSP)患者の剖検例においてタウ病理の分布が報告されているが、症候とタウ蓄積の関係は十分明らかにされていない。タウに高い親和性を持つ[11C]-PBBを用いたPETスキャンを行い、タウ蓄積と臨床情報との関係を検討した。\n方法: 対象はPSP患者14名（69.6±8.3歳[mean±SD]; 罹病期間4.9±3.0年; UPDRS part Ⅲ 38.3±17.6）; PSPRS 40.7±11.7, N=10)と年齢をマッチさせた健常対照(HC)18名（68.2±4.3歳）とした。[11C]-PBB3 PET、[11C]-PIB PETを施行し、小脳を参照領域としたstandardized uptake value ratio (SUVR)画像を作成した。[11C]-PBB PETはSUVR画像を解剖学的標準化した後、規定atlasを用いて各大脳皮質・白質、視床、線条体、脳幹、小脳歯状核にregion of interest (ROI)を置き、一部用手的にROIを作成し、各ROIの集積平均値を解析に用いた。脳萎縮は個々の全頭蓋内容積で補正し、容積を比較した。[11C]-PIB PETはSUVR画像を用いた視覚判定で大脳β amyloid沈着の有無を確認した。統計解析はHC群のうちMini-Mental State Examinationで24点であった1名と[11C-PIB]集積を認めた1名を除外し、PSP群と比較した(Mann-Whiteney U test with Dunn-Sidak Correction)。PSPの臨床情報、[11C]-PBB3の集積の相関はspearman順位相関係数で検定した。\n結果: PSP群とHC群のROI解析では補足運動野(p=0.01)、淡蒼球(p=0.049)、タウ蓄積の多いところへ領域設定した中脳(p=0.049)で有意に高い[11C]-PBB3集積を認めた。[11C]-PBB3集積とUPDRSは規定atlasの中脳ROI、視床ROIでそれぞれr= -0.59, p= 0.03、r= -0.66, p=0.01と負の相関を認めた。淡蒼球では相関は認めなかったが、PSPRSが軽度～中等度の患者で特に上昇していた。脳萎縮は健常群と比較して補足運動野、視床、被殻、淡蒼球、尾状核、中脳、小脳歯状\n核で有意に容積低下していた(p=0.003以下)。\n考察：タウ蓄積は、特に脳幹部、基底核では萎縮の影響を受ける可能性が考えられた。\n結論: [11C]-PBB3 PETを用いてPSPにおける特徴的なタウの蓄積が捉えられた。タウイメージングにてタウ蓄積と臨床症状、脳萎縮との関係を明らかにできる可能性が示された。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第56回日本神経学会学術大会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"遠藤, 浩信"}],"nameIdentifiers":[{"nameIdentifier":"834376","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田, 斉"}],"nameIdentifiers":[{"nameIdentifier":"834377","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"篠遠, 仁"}],"nameIdentifiers":[{"nameIdentifier":"834378","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"丹羽, 文俊"}],"nameIdentifiers":[{"nameIdentifier":"834379","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"北村, 聡一郎"}],"nameIdentifiers":[{"nameIdentifier":"834380","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"平野, 成樹"}],"nameIdentifiers":[{"nameIdentifier":"834381","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古川, 彰吾"}],"nameIdentifiers":[{"nameIdentifier":"834382","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"樋口, 真人"}],"nameIdentifiers":[{"nameIdentifier":"834383","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原, 哲也"}],"nameIdentifiers":[{"nameIdentifier":"834384","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Endo, Hironobu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"834385","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimada, Hitoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"834386","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shinoto, Hitoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"834387","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Niwa, Fumitoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"834388","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kitamura, Soichiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"834389","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hirano, Shigeki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"834390","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Furukawa, Shogo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"834391","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Higuchi, Makoto","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"834392","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suhara, Tetsuya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"834393","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Progressive supranuclear palsy患者における臨床症候と[11C]-PBB3 PET集積の関係","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Progressive supranuclear palsy患者における臨床症候と[11C]-PBB3 PET集積の関係"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-06-01"},"publish_date":"2015-06-01","publish_status":"0","recid":"65662","relation_version_is_last":true,"title":["Progressive supranuclear palsy患者における臨床症候と[11C]-PBB3 PET集積の関係"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T22:56:01.112306+00:00"}