{"created":"2023-05-15T14:47:50.744813+00:00","id":65596,"links":{},"metadata":{"_buckets":{"deposit":"12adf68b-8b8c-480f-a07f-00ab0eb58164"},"_deposit":{"created_by":1,"id":"65596","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"65596"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00065596","sets":["10:29"]},"author_link":["645996","646001","646000","646004","646003","645995","645999","646002","645998","645997"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2015-03-10","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"これまでのES細胞を用いた方法でノックアウト（KO）マウスを作出するためには年単位の時間が必要であった。仮にKOマウス作出に成功したとして、必ずしも期待した表現型を示すとは限らず、結果的に時間と研究費をロスすることも多かった。しかし、近年登場したCRISPR/Cas9をはじめとするゲノム編集ツールの普及によって、この状況は一変し遺伝子改変新時代が到来した。この技術を用いることで、これまで年単位の時間が必要であったノックアウトマウス作出も最短で１ヶ月ほどで可能となった。CRISPR/Cas9システムを用いたノックアウトマウス作出の流れや応用例などを紹介することで、ゲノム編集ツールの利点や今後の展望について発表したい。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第9回技術と安全の報告会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"塚本, 智史"}],"nameIdentifiers":[{"nameIdentifier":"645995","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊林, 恵美"}],"nameIdentifiers":[{"nameIdentifier":"645996","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"和田, 彩子"}],"nameIdentifiers":[{"nameIdentifier":"645997","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鬼頭, 靖司"}],"nameIdentifiers":[{"nameIdentifier":"645998","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小久保, 年章"}],"nameIdentifiers":[{"nameIdentifier":"645999","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"塚本 智史","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"646000","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊林 恵美","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"646001","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"和田 彩子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"646002","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鬼頭 靖司","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"646003","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小久保 年章","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"646004","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"革新的遺伝子改変技術：CRISPR/Cas9システムによるノックアウトマウスの作出","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"革新的遺伝子改変技術：CRISPR/Cas9システムによるノックアウトマウスの作出"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-03-19"},"publish_date":"2015-03-19","publish_status":"0","recid":"65596","relation_version_is_last":true,"title":["革新的遺伝子改変技術：CRISPR/Cas9システムによるノックアウトマウスの作出"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:58:20.946434+00:00"}