{"created":"2023-05-15T14:47:49.124471+00:00","id":65560,"links":{},"metadata":{"_buckets":{"deposit":"3b8ba651-8359-496c-a5d7-12cbdbdd1f5c"},"_deposit":{"created_by":1,"id":"65560","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"65560"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00065560","sets":["10:29"]},"author_link":["645658","645653","645646","645644","645657","645649","645654","645650","645647","645652","645645","645656","645651","645655","645648"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2014-12-20","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"放射線による組織内レドックス状態の変化とその時間的変化は、「診断治療」を目指す将来の放射線治療において、重要な鍵となる。本研究では、正常マウス脳についてX線または炭素線照射後のレドックス状態変化を経時的に解析した。放射線をマウス頭部に照射した1、2、4、8日後に7 T水平型MRIにてMC-PROXYLを造影剤として連続撮像を行い、その信号強度の減衰速度を解析して脳内のレドックス状態を評価した。MC-PROXYLの二相性の減衰曲線で、主にラジカルの還元を示す初期減衰速度の観察から、照射1～2日後に組織のレドックス変化が起こっていると考えられた。主にクリアランスを示す二相目の減衰速度は、8 Gy X線照射群と8 Gy炭素線照射群で照射1日後の減衰速度が速くなり、16 Gy炭素線照射群は減衰速度が遅くなった。この減衰速度の増加は膜透過性の亢進が考えられ、減衰速度の低下は血流の低下の影響が考えられる。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第 29 回日本酸化ストレス学会関東支部会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"中村, 美月"}],"nameIdentifiers":[{"nameIdentifier":"645644","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"柴田, さやか"}],"nameIdentifiers":[{"nameIdentifier":"645645","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"尾澤, 芳和"}],"nameIdentifiers":[{"nameIdentifier":"645646","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"上野, 恵美"}],"nameIdentifiers":[{"nameIdentifier":"645647","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松本, 謙一郎"}],"nameIdentifiers":[{"nameIdentifier":"645648","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山田, 健一"}],"nameIdentifiers":[{"nameIdentifier":"645649","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鎌田, 正"}],"nameIdentifiers":[{"nameIdentifier":"645650","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"青木, 伊知男"}],"nameIdentifiers":[{"nameIdentifier":"645651","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中村 美月","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"645652","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"柴田 さやか","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"645653","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"尾澤 芳和","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"645654","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"上野 恵美","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"645655","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松本 謙一郎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"645656","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鎌田 正","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"645657","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"青木 伊知男","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"645658","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"放射線照射後の組織におけるレドックス状態変化の解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"放射線照射後の組織におけるレドックス状態変化の解析"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-01-08"},"publish_date":"2015-01-08","publish_status":"0","recid":"65560","relation_version_is_last":true,"title":["放射線照射後の組織におけるレドックス状態変化の解析"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:58:45.196021+00:00"}