{"created":"2023-05-15T14:47:47.760708+00:00","id":65531,"links":{},"metadata":{"_buckets":{"deposit":"430eae5f-d7cb-4301-ac31-747574b91d0c"},"_deposit":{"created_by":1,"id":"65531","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"65531"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00065531","sets":["10:29"]},"author_link":["838998","839001","839002","838992","839003","839004","838996","838997","838989","838986","838990","838993","838995","838987","838999","839000","838991","838988","838994"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2014-11-07","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【目的】ドーパミントランスポーター(DAT)リガンド[18F]FEPE2Iの結合は、薬物負荷や疾患による内因性ドーパミン(DA)濃度変化の影響を受ける可能性が示唆されている。本研究では、ラットを用いて遮断薬ハロペリドル(HAL)急性投与時の内因性DA濃度上昇による[18F]FEPE2Iの線条体DATへの結合阻害の有無を調べた。\n【方法】雄性SDラット(n=4)を用い、各個体でベースライン条件、HAL投与条件（i.v. 0.1 mg/kg）の2回のPET実験を実施した。線条体への[18F]FEPE2I結合は小脳を参照領域とした参照領域法によるBPNDで算出し、HAL投与によるBPNDの変化率を各個体で求め、paired t-testで検定した。\n【結果】HAL投与条件でのBPNDはベースラインに対し、11.8±4.8%(p<0.05)上昇した。\n【結論】HAL投与によるシナプス間隙のDA濃度上昇は、DATへの[18F]FEPE2I結合を阻害しないことが示唆された。\n","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第54回日本核医学会学術総会にて口頭発表を行う。","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"関, 千江"}],"nameIdentifiers":[{"nameIdentifier":"838986","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"徳永, 正希"}],"nameIdentifiers":[{"nameIdentifier":"838987","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小高, 文聰"}],"nameIdentifiers":[{"nameIdentifier":"838988","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"前田, 純"}],"nameIdentifiers":[{"nameIdentifier":"838989","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"木村, 泰之"}],"nameIdentifiers":[{"nameIdentifier":"838990","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田桑, 弘之"}],"nameIdentifiers":[{"nameIdentifier":"838991","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"生駒, 洋子"}],"nameIdentifiers":[{"nameIdentifier":"838992","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原, 哲也"}],"nameIdentifiers":[{"nameIdentifier":"838993","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"樋口, 真人"}],"nameIdentifiers":[{"nameIdentifier":"838994","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤浩"}],"nameIdentifiers":[{"nameIdentifier":"838995","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Seki, Chie","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"838996","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tokunaga, Masaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"838997","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kodaka, Fumitoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"838998","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Maeda, Jun","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"838999","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kimura, Yasuyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"839000","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takuwa, Hiroyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"839001","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ikoma, Yoko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"839002","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suhara, Tetsuya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"839003","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Higuchi, Makoto","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"839004","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"ハロペリドル急性投与によるラット線条体へのドーパミントランスポーターリガンド[18F]FEPE2Iの結合変化","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ハロペリドル急性投与によるラット線条体へのドーパミントランスポーターリガンド[18F]FEPE2Iの結合変化"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-11-10"},"publish_date":"2014-11-10","publish_status":"0","recid":"65531","relation_version_is_last":true,"title":["ハロペリドル急性投与によるラット線条体へのドーパミントランスポーターリガンド[18F]FEPE2Iの結合変化"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T22:50:36.690962+00:00"}