{"created":"2023-05-15T14:47:44.914312+00:00","id":65467,"links":{},"metadata":{"_buckets":{"deposit":"67ae39a0-0b72-4bba-88b0-60aa54219a84"},"_deposit":{"created_by":1,"id":"65467","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"65467"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00065467","sets":["10:29"]},"author_link":["644843","644842","644836","644838","644834","644835","644841","644840","644839","644837"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2014-05-22","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【目的】\n低酸素PETトレーサーである18F-FMISOと64Cu-ATSMは、腫瘍内分布は異なるが、腫瘍集積量は共に予後と相関することが知られている。本研究では、低酸素状態で転写活性を促進する低酸素応答因子(Hypoxia response elements; HRE)と99mTcO4-を細胞内に取り込むNa＋/I－共輸送タンパク(sodium/iodide symporter; NIS)を用いた低酸素応答イメージングを基準として、PET/SPECT同時収集イメージングにより18F-FMISOと64Cu-ATSMの集積分布と腫瘍集積量を比較した。\n【方法】低酸素下で99mTcO4-を取り込むヒト大腸癌細胞株(HCT116-12HRE-NIS)の担癌マウスを正常酸素(21%O2, n=10)と低酸素(10%O2・12時間, n=10)で飼育し18F-FMISOと99mTcO4-あるいは64Cu-ATSMと99mTcO4-の混合液を注射した(各群n=10)。2核種同時収集によるPET/SPECTデュアルイメージングを行い、腫瘍集積量(SUVmax)を算出した。\n【結果】低酸素PETトレーサー集積分布は99mTcO4-集積分布とオーバーラップ領域を認めたが異なる集積分布を示した。腫瘍集積量に関しては、低酸素PETトレーサーの腫瘍集積量(SUVmax)は共に遺伝子応答を表す99mTcO4-集積量と正の相関を認めた (18F-FMISO vs. 99mTcO4-: r = 0.91, p < 0.0001、64Cu-ATSM vs. 99mTcO4-: r = 0.74, p = 0.0005)。\n【結語】低酸素PETトレーサーと低酸素遺伝子応答は異なる分布を示したが、腫瘍集積量(SUVmax)は、腫瘍内における低酸素遺伝子応答の程度を間接的に反映していた。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第9回日本分子イメージング学会総会・学術集会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"竹内, 康人"}],"nameIdentifiers":[{"nameIdentifier":"644834","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"犬伏, 正幸"}],"nameIdentifiers":[{"nameIdentifier":"644835","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"村井, 知佳"}],"nameIdentifiers":[{"nameIdentifier":"644836","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"泰, 浩信"}],"nameIdentifiers":[{"nameIdentifier":"644837","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"北川, 義政"}],"nameIdentifiers":[{"nameIdentifier":"644838","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐賀, 恒夫"}],"nameIdentifiers":[{"nameIdentifier":"644839","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"竹内 康人","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"644840","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"犬伏 正幸","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"644841","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"村井 知佳","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"644842","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐賀 恒夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"644843","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"腫傷内の低酸素遺伝子応答と低酸素ＰＥＴトレーサー集積の関係","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"腫傷内の低酸素遺伝子応答と低酸素ＰＥＴトレーサー集積の関係"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-06-03"},"publish_date":"2014-06-03","publish_status":"0","recid":"65467","relation_version_is_last":true,"title":["腫傷内の低酸素遺伝子応答と低酸素ＰＥＴトレーサー集積の関係"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:59:44.847254+00:00"}