{"created":"2023-05-15T14:47:41.602385+00:00","id":65392,"links":{},"metadata":{"_buckets":{"deposit":"b484daee-03b1-421b-806c-a33603039dbb"},"_deposit":{"created_by":1,"id":"65392","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"65392"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00065392","sets":["10:29"]},"author_link":["644191","644195","644200","644201","644197","644196","644198","644203","644199","644208","644189","644206","644204","644190","644193","644205","644202","644192","644207","644210","644209","644194"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2013-11-07","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【目的】 [<sup>11</sup>C]PBB3はタウイメージング用の新規PETリガンドであり, タ\nウ蛋白病変への高い親和性と選択性が認められることが予備的な研究でわかってきて\nいる. 本研究では認知機能障害患者及び健常高齢者における[<sup>11</sup>C]PBB3 P\nETによるタウイメージングの特徴を検討した.\n【対象・方法】対象はAD10例, 軽度認\n知機能障害(MCI)10例, 健常高齢者12例. [<sup>11</sup>C]PBB3 PET及び[<sup>11</s\nup>C]PIB PETを施行し, 小脳皮質の集積で標準化したSUVR画像を作成し, PBB3集積の\n特徴を検討した.\n【結果】AD群全例とMCI群10例中6例で有意なPIB集積を認めた. PIB\n陽性AD及びMCI症例では, PIB集積の乏しい側頭葉内側面にPBB3の強い集積を認めた.\nPBB3の集積は認知機能障害が強くなるに従い, 辺縁系から新皮質に及んでいた. 健常\n高齢者でも側頭葉内側面にPBB3集積を認める症例では, 傍海馬領域に軽度萎縮を認め\nた.\n【結論】PBB3はPIBとは異なる集積分布を呈しており, タウ蛋白病変の分布を反映\nしていると考えられた. さらにPBB3の結合は, Braakのタウステージの進展と類似し\nた, 病期を反映したものと考えられた","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第53回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"島田, 斉"}],"nameIdentifiers":[{"nameIdentifier":"644189","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"篠遠, 仁"}],"nameIdentifiers":[{"nameIdentifier":"644190","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"平野, 成樹"}],"nameIdentifiers":[{"nameIdentifier":"644191","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"江口, 洋子"}],"nameIdentifiers":[{"nameIdentifier":"644192","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"木村, 泰之"}],"nameIdentifiers":[{"nameIdentifier":"644193","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高畑, 圭輔"}],"nameIdentifiers":[{"nameIdentifier":"644194","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小高, 文聰"}],"nameIdentifiers":[{"nameIdentifier":"644195","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高野, 晴成"}],"nameIdentifiers":[{"nameIdentifier":"644196","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤, 浩"}],"nameIdentifiers":[{"nameIdentifier":"644197","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"樋口, 真人"}],"nameIdentifiers":[{"nameIdentifier":"644198","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原, 哲也"}],"nameIdentifiers":[{"nameIdentifier":"644199","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田 斉","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"644200","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"篠遠 仁","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"644201","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"平野 成樹","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"644202","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"江口 洋子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"644203","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"木村 泰之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"644204","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高畑 圭輔","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"644205","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小高 文聰","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"644206","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高野 晴成","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"644207","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤 浩","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"644208","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"樋口 真人","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"644209","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原 哲也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"644210","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"[11C]PBB3 PETによるタウイメージング","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"[11C]PBB3 PETによるタウイメージング"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-12-18"},"publish_date":"2013-12-18","publish_status":"0","recid":"65392","relation_version_is_last":true,"title":["[11C]PBB3 PETによるタウイメージング"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:00:36.766116+00:00"}