{"created":"2023-05-15T14:47:41.381270+00:00","id":65387,"links":{},"metadata":{"_buckets":{"deposit":"13b7e5d3-0901-473d-a526-0a7001c295ff"},"_deposit":{"created_by":1,"id":"65387","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"65387"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00065387","sets":["10:29"]},"author_link":["644163","644165","644154","644158","644157","644160","644162","644159","644167","644153","644164","644156","644166","644152","644155","644161"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2013-12-14","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"5-アミノレブリン酸 (ALA) を用いた光線力学療法 (PDT) では、腫瘍に蓄積するプロトポルフィリンIX (PpIX) 量が治療効果に大きく影響する。ALA投与時のPpIX蓄積量を定量評価する方法を開発するため、ALAと類似した機序で細胞に取り込まれ、PpIX合成に関わる酵素 (ALAD) の発現量に応じて蓄積するPETプローブとして、ALAの5位に[11C]メチル基を導入した[11C]MALAを合成した。細胞実験において、[11C]MALAの取り込みはALAにより阻害され、また、その取り込み量はALAD発現量およびPpIX蓄積量と相関した。皮下腫瘍移植マウスにおける[11C]MALA腫瘍集積およびALA投与時のPpIX蓄積量を評価したところ、[11C]MALAの腫瘍への集積はPpIX蓄積量と良好な相関を示し、[11C]MALA-PETは、ALAを用いたPDTの治療効果予測に有用な情報を与えることが期待された。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第13回放射性医薬品・画像診断薬研究会に参加発表をする","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"鈴木, 千恵"}],"nameIdentifiers":[{"nameIdentifier":"644152","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻, 厚至"}],"nameIdentifiers":[{"nameIdentifier":"644153","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"菊池, 達矢"}],"nameIdentifiers":[{"nameIdentifier":"644154","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"加藤, 孝一"}],"nameIdentifiers":[{"nameIdentifier":"644155","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須尭, 綾"}],"nameIdentifiers":[{"nameIdentifier":"644156","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須藤, 仁美"}],"nameIdentifiers":[{"nameIdentifier":"644157","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"荒野, 泰"}],"nameIdentifiers":[{"nameIdentifier":"644158","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐賀, 恒夫"}],"nameIdentifiers":[{"nameIdentifier":"644159","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鈴木 千恵","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"644160","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻 厚至","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"644161","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"菊池 達矢","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"644162","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"加藤 孝一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"644163","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須尭 綾","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"644164","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須藤 仁美","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"644165","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"荒野 泰","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"644166","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐賀 恒夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"644167","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"5-アミノレブリン酸を使用した光線力学療法の治効果予測する PETプローブの プローブの 開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"5-アミノレブリン酸を使用した光線力学療法の治効果予測する PETプローブの プローブの 開発"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-12-17"},"publish_date":"2013-12-17","publish_status":"0","recid":"65387","relation_version_is_last":true,"title":["5-アミノレブリン酸を使用した光線力学療法の治効果予測する PETプローブの プローブの 開発"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:00:40.630981+00:00"}