{"created":"2023-05-15T14:47:37.945741+00:00","id":65309,"links":{},"metadata":{"_buckets":{"deposit":"2e27de34-6cb9-4f8b-83c2-0f34ebaf5b9c"},"_deposit":{"created_by":1,"id":"65309","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"65309"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00065309","sets":["10:29"]},"author_link":["643583","643586","643580","643582","643584","643578","643581","643579","643585","643577"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2013-11-10","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【目的】低酸素PETトレーサの18F-FMISOと64Cu-ATSMは、腫瘍内分布は異なるが、腫瘍集積は予後と相関することが知られている。前回我々はex vivoで18F-FMISO・64Cu-ATSM集積分布は、低酸素応答領域と完全に一致しないことを報告した。本研究ではin vivoで低酸素PETトレーサと低酸素応答領域の集積分布と腫瘍集積を比較した。【方法】低酸素下で99mTcを取り込むヒト大腸癌細胞株(HCT116-12HRE-NIS)の担癌マウスを正常酸素(21%O2, n=10)と低酸素(10%O2・12時間, n=10)で飼育し18F-FMISOと99mTcあるいは64Cu-ATSMと99mTc の混合液を注射した(各群n=10)。2核種同時収集によるPET/SPECTデュアルイメージングを行い腫瘍集積(SUVmax)を算出した。【結果】低酸素PETトレーサ集積分布は99mTc集積分布とオーバーラップ領域を認めたが異なる集積分布を示した。また低酸素PETトレーサ集積(SUVmax)は99mTc集積と正の相関を認めた (18F-FMISO vs 99mTc: R = 0.74, p = 0.01、64Cu-ATSM vs 99mTc: R = 0.74, p = 0.01)。【結語】低酸素PETトレーサと低酸素応答領域は異なる集積分布だが腫瘍集積(SUVmax)は間接的に遺伝子応答の程度を反映した。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第53回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"竹内, 康人"}],"nameIdentifiers":[{"nameIdentifier":"643577","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"犬伏, 正幸"}],"nameIdentifiers":[{"nameIdentifier":"643578","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"村井, 知佳"}],"nameIdentifiers":[{"nameIdentifier":"643579","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"北川, 善政"}],"nameIdentifiers":[{"nameIdentifier":"643580","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐賀, 恒夫"}],"nameIdentifiers":[{"nameIdentifier":"643581","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"その他"}],"nameIdentifiers":[{"nameIdentifier":"643582","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"竹内 康人","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"643583","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"犬伏 正幸","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"643584","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"村井 知佳","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"643585","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐賀 恒夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"643586","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"腫瘍内の低酸素遺伝子応答と低酸素PETトレーサ集積の関係","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"腫瘍内の低酸素遺伝子応答と低酸素PETトレーサ集積の関係"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-11-15"},"publish_date":"2013-11-15","publish_status":"0","recid":"65309","relation_version_is_last":true,"title":["腫瘍内の低酸素遺伝子応答と低酸素PETトレーサ集積の関係"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:01:35.318404+00:00"}