{"created":"2023-05-15T14:47:35.689430+00:00","id":65258,"links":{},"metadata":{"_buckets":{"deposit":"c7ff8689-50e6-4871-a90a-f0afeded97e3"},"_deposit":{"created_by":1,"id":"65258","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"65258"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00065258","sets":["10:29"]},"author_link":["643019","643024","643015","643013","643018","643026","643027","643017","643021","643023","643014","643028","643022","643025","643016","643020"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2013-11-10","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"[11C]racloprideのドーパミン受容体への結合は内在性ドーパミンと拮抗し、受容体結合能(BP)の増減を調べることでドーパミン放出量の変化を間接的に評価できる。近年、1回のPET検査で安静時と負荷時のBPを算出する連続ボーラス法が開発された。本研究では、ドーパミン放出の短時間・高精度測定法の確立に向け、連続ボーラス法による安静時BPの再現性を検討した。若年健常者10名を対象に、連続ボーラス法と持続投与法による安静時PET検査を別日に行った。連続ボーラス法では、スキャン開始時および45分後に[11C]racloprideボーラス投与を行い、0-40分および45-85分の測定データから、2回の線条体BPを残存放射能を考慮した参照領域法で算出した。持続投与法では、総投与量の約半分をスキャン開始と同時にボーラス投与、残りを100分間持続投与し、40-52分および68-100分の線条体/小脳比から2回のBPを求めた。その結果、両手法とも2回のBP値の差は平均5%以下であった。連続ボーラス法は再現性も良く、認知課題負荷によるドーパミン放出の測定に有用であると期待される。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第53回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"生駒, 洋子"}],"nameIdentifiers":[{"nameIdentifier":"643013","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"木村, 泰之"}],"nameIdentifiers":[{"nameIdentifier":"643014","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高野, 晴成"}],"nameIdentifiers":[{"nameIdentifier":"643015","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小高, 文聰"}],"nameIdentifiers":[{"nameIdentifier":"643016","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤原, 広臨"}],"nameIdentifiers":[{"nameIdentifier":"643017","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山田, 真希子"}],"nameIdentifiers":[{"nameIdentifier":"643018","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原, 哲也"}],"nameIdentifiers":[{"nameIdentifier":"643019","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤, 浩"}],"nameIdentifiers":[{"nameIdentifier":"643020","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"生駒 洋子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"643021","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"木村 泰之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"643022","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高野 晴成","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"643023","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小高 文聰","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"643024","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤原 広臨","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"643025","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山田 真希子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"643026","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原 哲也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"643027","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤 浩","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"643028","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"[11C]raclopride 連続ボーラス投与法を用いたドーパミン放出量測定における安静時結合能の再現性の検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"[11C]raclopride 連続ボーラス投与法を用いたドーパミン放出量測定における安静時結合能の再現性の検討"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-11-12"},"publish_date":"2013-11-12","publish_status":"0","recid":"65258","relation_version_is_last":true,"title":["[11C]raclopride 連続ボーラス投与法を用いたドーパミン放出量測定における安静時結合能の再現性の検討"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:02:10.986147+00:00"}