@misc{oai:repo.qst.go.jp:00065241,
 author = {崔, 星 and 若井, 俊文 and Ｇｕｉｌｌａｕｍｅ, Ｖａｒｅｓ and 王, 冰 and 根井, 充 and 上條, 岳彦 and 白井, 敏之 and 鎌田, 正 and 崔 星 and Ｇｕｉｌｌａｕｍｅ Ｖａｒｅｓ and 王 冰 and 根井 充 and 上條 岳彦 and 白井 敏之 and 鎌田 正},
 month = {Oct},
 note = {Here we report the role of XRCC4 in cancer stem cell (CSC) properties and radiosensitivity of CSCs to X-ray and carbon ion beam. FACS analysis showed that the CSCs (CD133+, CD44+/ESA+) were significantly altered in XRCC4 KO cells compared to HCT116-WT cells. The number of colony and spheroid formed from CSCs were significantly higher compared to that from non-CSCs in XRCC4 KO cells, but extremely decreased compared to HCT116-WT cells. The proportion of CSCs was more extremely increased in XRCC4 KO cells compared to HCT116-WT cells after X-ray irradiation. Survival fraction analysis showed that the doses at D10 levels of CSCs sorted from XRCC4-KO and HCT116-WT cells were 1.4 and 4.2 Gy for X-ray and 1.0 and 1.9 Gy for carbon ion beam, respectively. A much more large number and large-sized gamma-H2AX foci were observed in CSCs sorted from XRCC4 KO cells compared to that from HCT116-WT cells, after 24 h carbon ion beam compared to X-ray irradiation. In conclusion, lack of XRCC4 significantly altered expression of CSC markers, radiosensitized CSCs to both X-ray and carbon ion beam, suggesting that XRCC4 may play a pivotal role in modulating cancer cell stemness., 第72回日本癌学会},
 title = {XRCC4遺伝子欠損によるヒト大腸癌幹細胞マーカー発現変化及びX線、炭素線に対する感受性増強},
 year = {2013}
}