@misc{oai:repo.qst.go.jp:00065180,
 author = {Shimokawa, Takashi and Fujita, Hidetoshi and Sato, Katsutoshi and Nakawatari, Miyako and Fujita, Tomoko and Moritake, Hiroyuki and Ando, Ken and Irie, Daisuke and Imai, Takashi and 下川 卓志 and 藤田 英俊 and 佐藤 克俊 and 中渡 美也子 and 藤田 知子 and 森竹 浩之 and 安藤 謙 and 入江 大介 and 今井 高志},
 month = {May},
 note = {Radiation induced pneumonitis and consequential pulmonary fibrosis are known serious side effects after thoracic radiation therapy. Since these side effects act as dose-limiting factors, understanding the molecular and pathogenic mechanisms underlying these symptoms is essential for improvement of radiotherapy, including heavy ion radiotherapy.
In this study, we aim to identify molecular mechanisms, which can become novel targets for prevention or treatment of radiation induced pneumonitis and pulmonary fibrosis. To find biomarkers for prediction of prognosis or molecular targets for treatment of radiation pneumonitis/fibrosis, we have investigated strain-dependent variation of pulmonary pneumonitis/fibrosis in fibrosis-prone (C57BL/6J) and fibrosis-resistant (C3H/He) mice strains after thoracic heavy ion irradiation. In the mouse model, mild fibrotic loci and infiltration of inflammatory cells were observed in both mouse strains 24 weeks after 10Gy carbon ion irradiation. Interestingly, fibrotic loci developed and expanded, changing the shape of the lung in C57BL/6J mice, but not in C3H/He mice. Our recent analysis clearly highlighted that the type of infiltrated inflammatory cells, and the difference in expression of lung remodeling proteins at these fibrotic loci, are critical factors in developing severe fibrosis after irradiation in a strain dependent manner.
In this symposium, I will present our recent results concerning late lung injury after carbon ion irradiation., Heavy Ion in Therapy and Space Radiation Symposium 2013 (HITSRS2013)},
 title = {Elucidating the Mechanisms Behind Late Lung Injury after Carbon Ion Beam Irradiation},
 year = {2013}
}