{"created":"2023-05-15T14:47:31.178983+00:00","id":65157,"links":{},"metadata":{"_buckets":{"deposit":"08f88fac-d355-455b-bd8f-f1f03813e7d0"},"_deposit":{"created_by":1,"id":"65157","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"65157"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00065157","sets":["10:29"]},"author_link":["642019","642018","642012","642015","642013","642014","642022","642016","642025","642017","642021","642020","642024","642023"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2013-08-28","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"発がんは，癌遺伝子や癌抑制遺伝子の変異や欠失といったゲノムDNAの配列異常や，DNAメチル化に代表されるエピジェネティックな異常の蓄積によって多段階的に進行する。しかしながら，エピジェネティックな発がん機構が，放射線による発がんにどの程度関わっているかについての知見は，乏しい。\n我々は，ラット乳腺腫瘍モデルを用いて，放射線誘発乳癌におけるエピジェネティックな異常と，その特徴を明らかにすることを目的とし，これまでに，自然発症した乳癌と被ばく時年齢の異なる放射線誘発乳癌におけるDNAメチル化と遺伝子発現異常の網羅的解析を行った。 その結果，自然発症あるいは放射線誘発乳癌に特徴的なDNAメチル化異常と遺伝子発現異常を伴う癌関連遺伝子候補を同定した。 この結果は，自然発症および放射線誘発乳癌における発がん機構の違いを示唆すると共に，放射線誘発乳癌をDNAメチル化状態の変化により識別できる可能性を示唆している。 また，ヒト乳癌と共通したゲノム異常を示すラット乳腺腫瘍モデルとして，乳がん高発系および低発系ラットとの雑種第一代に誘発された乳癌のDNAメチル化異常の特徴について紹介する。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第28回発癌病理研究会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"臺野, 和広"}],"nameIdentifiers":[{"nameIdentifier":"642012","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高畠, 賢"}],"nameIdentifiers":[{"nameIdentifier":"642013","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"西村, まゆみ"}],"nameIdentifiers":[{"nameIdentifier":"642014","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"森岡, 孝満"}],"nameIdentifiers":[{"nameIdentifier":"642015","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"柿沼, 志津子"}],"nameIdentifiers":[{"nameIdentifier":"642016","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今岡, 達彦"}],"nameIdentifiers":[{"nameIdentifier":"642017","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田, 義也"}],"nameIdentifiers":[{"nameIdentifier":"642018","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"臺野 和広","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"642019","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高畠 賢","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"642020","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"西村 まゆみ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"642021","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"森岡 孝満","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"642022","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"柿沼 志津子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"642023","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今岡 達彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"642024","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田 義也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"642025","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"放射線誘発ラット乳がんにおけるエピジェネティック異常","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"放射線誘発ラット乳がんにおけるエピジェネティック異常"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-09-26"},"publish_date":"2013-09-26","publish_status":"0","recid":"65157","relation_version_is_last":true,"title":["放射線誘発ラット乳がんにおけるエピジェネティック異常"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:03:23.788097+00:00"}