@misc{oai:repo.qst.go.jp:00065128,
 author = {王, 冰 and 田中, 薫 and 季, 斌 and 小野, 麻衣子 and 方, 雅群 and 二宮, 康晴 and 丸山, 耕一 and 中島, 菜花子 and ＢＥＧＵＭ, ＮＡＳＲＩＮ and 樋口, 真人 and 藤森, 亮 and 上原, 芳彦 and 中島, 徹夫 and 須原, 哲也 and 小野, 哲也 and 根井, 充 and 王 冰 and 田中 薫 and 季 斌 and 小野 麻衣子 and 方 雅群 and 二宮 康晴 and 丸山 耕一 and 中島 菜花子 and ＢＥＧＵＭ ＮＡＳＲＩＮ and 樋口 真人 and 藤森 亮 and 中島 徹夫 and 須原 哲也 and 根井 充},
 month = {Sep},
 note = {Cause and progression of Alzheimer's disease (AD) are poorly understood. Possible cognitive and behavioral consequences induced by low-dose radiation are important because humans are exposed to ionizing radiation from various sources. Early transcriptional response in murine brain to low-dose X-rays (100 mGy) was reported, suggesting alterations of molecular networks and pathways associated with cognitive functions, advanced aging and AD. To investigate acute and late transcriptional, pathological and cognitive consequences of low-dose radiation, we applied an acute dose of 100 mGy total body irradiation (TBI) with X-rays to C57BL/6J Jms mice. We collected hippocampi and analyzed expression of 84 AD-related genes. Mouse learning ability and memory were assessed with Morris water maze test. We performed in vivo PET scans with 11C-PIB, a radiolabeled ligand for amyloid imaging, to detect fibrillary amyloid beta peptide (Abeta) accumulation and examined characteristic AD pathologies with immunohistochemical staining of amyloid precursor protein (APP), Abeta, tau and phosphorylated tau (p-tau). mRNA studies showed significant down-regulation of only 2 of 84 AD-related genes, Apbb1 and Lrp1, at 4 hours after irradiation, and of only 1 gene, Il1a, at 1 year after irradiation. Spatial learning ability and memory were not significantly affected at 1 or 2 years after irradiation. No induction of amyloid fibrillogenesis or changes in APP, Abeta, tau, and p-tau expression were detected at 4 months and 2 years after irradiation. TBI induced early or late transcriptional alteration in only a few AD-related genes but did not significantly affect spatial learning, memory and AD-like pathological change in mice., 第3回低線量放射線影響研究交流会},
 title = {低線量被ばくによるアルツハイマー病誘発の信憑性について},
 year = {2013}
}