@misc{oai:repo.qst.go.jp:00065102,
 author = {Karasawa, Kumiko and Kamada, Tadashi and 唐澤 久美子 and 鎌田 正},
 month = {Aug},
 note = {Introduction :
Breast cancer is a major health problem for women in all over the world. The standard care for early stage breast cancer is breast conserving therapy which consists of conservative surgery and fractionated whole breast irradiation. Fractionated irradiation takes more than 5 weeks and is a burden to patients. Accelerated Partial Breast Irradiation (APBI) is an alternative to fractionated whole breast irradiation in patients with low risk tumor. 
Objective :
We are about to conduct a clinical trial of radical APBI without surgery using carbon iron irradiation for patients with low risk tumor. A candidate of carbon ion treatment is T1N0M0, estrogen receptor (ER) positive, HER2 negative, invasive ductal carcinoma or other favorable type, without extensive intraductal component, lymph vascular space invasion, and tumor located more than 5 mm from skin. 
Methodology :
Carbon ion beams provide superior physical dose distribution because of their finite range in the target tissue, and they possess a biological advantage due to their high relative biological effectiveness in the Bragg peak. Since 1994, our institute has treated more than 7,000 cases of various malignancies. We plan to use dose escalation of 12 GyE, 13.2 GyE and 15 GyE per fraction and 4 fractions in one week for breast tumor. 
Results :
We finalized the technical preparation and ethical approval. 
Conclusion :
We will start clinical trial from April 2013. Just a four fractions of carbon ion radiotherapy could have a potential to be an alternative of surgery and conventional radiotherapy., 29th International Congress of the Medical Women's International Association},
 title = {Carbon Ion Radiotherapy for Early Breast Cancer},
 year = {2013}
}