{"created":"2023-05-15T14:47:28.617733+00:00","id":65099,"links":{},"metadata":{"_buckets":{"deposit":"6265109d-b7d8-4964-824a-87a8eeddd256"},"_deposit":{"created_by":1,"id":"65099","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"65099"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00065099","sets":["10:29"]},"author_link":["641456","641463","641465","641461","641464","641460","641462","641466","641459","641457","641458"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2013-07-21","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【目的】 ヒトに近い病理形態を持つ乳癌を発生するラットの乳癌を用いて、放射線誘発乳癌関連遺伝子を同定する。【方法】放射線誘発乳癌高発系Sprague-Dawley(SD)ラット（雌）と放射線誘発乳癌低発系Copenhagen(COP)ラット(雄)の雑種第一代(F1)ラット（雌）に対し、生後7週齢時にγ線4Gyを全身1回照射した。F1に発生した乳癌（腺癌21検体）について行われたaCGH解析の結果をもとに、LOH解析と乳癌関連候補遺伝子のシークエンス解析を行った。【結果】aCGH及びLOH解析によりコピー数の減少が顕著であった1、2番染色体の領域にコードされている遺伝子のうち、ヒト乳癌で異常がみつかっている遺伝子Pten、Pik3r1、Map3k1についてシークエンス解析を行った。すべての検体においてPten、Map3k1に変異は見られず、Pik3r1に18塩基の欠失型変異を1例発見した。【考察】Pik3r1は複数の機能ドメインから構成されており、今回欠失変異がみつかった部位はiSH2領域に位置していた。Pik3r1遺伝子のこの領域での配列異常は、ヒトの原発性子宮内膜がんで高頻度にみられ、ヒト乳癌でも報告されている。よってPik3r1は放射線誘発乳癌の関連遺伝子の1つである可能性が考えられる。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第2回三重先端がんフォーラム・第２２回乳癌基礎研究会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"ショウラー, 恵"}],"nameIdentifiers":[{"nameIdentifier":"641456","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"西村, まゆみ"}],"nameIdentifiers":[{"nameIdentifier":"641457","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"臺野, 和広"}],"nameIdentifiers":[{"nameIdentifier":"641458","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今岡, 達彦"}],"nameIdentifiers":[{"nameIdentifier":"641459","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"福士, 政広"}],"nameIdentifiers":[{"nameIdentifier":"641460","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田, 義也"}],"nameIdentifiers":[{"nameIdentifier":"641461","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ショウラー 恵","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"641462","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"西村 まゆみ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"641463","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"臺野 和広","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"641464","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今岡 達彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"641465","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田 義也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"641466","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"放射線誘発ラット乳癌における遺伝子変異の解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"放射線誘発ラット乳癌における遺伝子変異の解析"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-08-08"},"publish_date":"2013-08-08","publish_status":"0","recid":"65099","relation_version_is_last":true,"title":["放射線誘発ラット乳癌における遺伝子変異の解析"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:04:04.792414+00:00"}