{"created":"2023-05-15T14:47:27.737691+00:00","id":65079,"links":{},"metadata":{"_buckets":{"deposit":"a39abb76-2fd7-4192-b315-65504b7b96c4"},"_deposit":{"created_by":1,"id":"65079","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"65079"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00065079","sets":["10:29"]},"author_link":["641299","641306","641297","641304","641302","641296","641305","641295","641301","641308","641309","641311","641298","641303","641310","641300","641307"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2013-07-21","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【目的】局所進行子宮頚部扁平上皮癌に対する重粒子線単独による臨床試験の治療成績を解析し，有用性を検討した．【対象・方法】1997年から2012年3月に3つの臨床試験 (プロトコール9702，9902，0508) を施行した．対象は，局所進行子宮頸癌（FIGO IIb 4cm以上，IIIb，IVa）で，9702，9902は全骨盤照射後の局所腫瘍への線量増加試験として行い，0508は傍大動脈リンパ節領域への予防照射を含めた．全体で62例（IIb: 14例，IIIb: 38例，Iva: 10例）が登録され，年齢の中央値は59歳 (31-80歳)，腫瘍最大径の中央値は6.4 (4-12) cm，総線量は64.0 - 68.8GyE 23例，72.0 - 72.8GyE 39例であった．【成績】観察期間の中央値は28か月 (4-160か月)，全体の5年生存率53.8％，5年局所制御率73.1％であった．Grade2以上の有害事象は急性期では消化管Grade2が 6例（9.7%）膀胱Grade2が 1例 (1.6％)で，Grade3以上はなく，晩期では消化管Grade2が5例 (8.1％)，Grade3-4が2例 (3.2％：初期の9702のみ)，膀胱Grade2が7例（11.3%）に認められた．64.0-68.8 GyEと72.0-72.8 GyEの比較では，5年局所制御率は60.9％と80.6％，5年全生存率は39.1％と61.1％であり，72.0GyE以上で良好な結果であった．両群で有害事象の発現頻度に有意な差はなかった．【結論】局所進行子宮頸部扁平上皮癌に対する重粒子線治療では特に72.0GyE以上での局所制御率・生存率は良好であり，従来の放射線療法では制御が困難と考えられる局所進行例で有用性が示唆された．","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第５４回日本婦人科腫瘍学会学術講演会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"若月, 優"}],"nameIdentifiers":[{"nameIdentifier":"641295","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"加藤, 真吾"}],"nameIdentifiers":[{"nameIdentifier":"641296","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大野, 達也"}],"nameIdentifiers":[{"nameIdentifier":"641297","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"唐澤, 久美子"}],"nameIdentifiers":[{"nameIdentifier":"641298","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"清原, 浩樹"}],"nameIdentifiers":[{"nameIdentifier":"641299","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安藤, 謙"}],"nameIdentifiers":[{"nameIdentifier":"641300","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"入江, 大介"}],"nameIdentifiers":[{"nameIdentifier":"641301","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中野, 隆史"}],"nameIdentifiers":[{"nameIdentifier":"641302","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鎌田, 正"}],"nameIdentifiers":[{"nameIdentifier":"641303","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"生水, 真紀夫"}],"nameIdentifiers":[{"nameIdentifier":"641304","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"若月 優","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"641305","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"加藤 眞吾","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"641306","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"唐澤 久美子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"641307","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安藤 謙","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"641308","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"入江 大介","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"641309","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鎌田 正","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"641310","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"生水 真紀夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"641311","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"局所進行子宮頸部扁平上皮癌に対する重粒子線単独の臨床試験成績","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"局所進行子宮頸部扁平上皮癌に対する重粒子線単独の臨床試験成績"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-07-22"},"publish_date":"2013-07-22","publish_status":"0","recid":"65079","relation_version_is_last":true,"title":["局所進行子宮頸部扁平上皮癌に対する重粒子線単独の臨床試験成績"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:04:18.831137+00:00"}