@misc{oai:repo.qst.go.jp:00065031,
 author = {Wakatuki, Masaru and Kato, Shingo and Ohno, Tatsuya and Karasawa, Kumiko and Ando, Ken and Kiyohara, Hiroki and Irie, Daisuke and Nakano, Takashi and Kamada, Tadashi and Syozu, Makio and 若月 優 and 加藤 眞吾 and 唐澤 久美子 and 安藤 謙 and 入江 大介 and 鎌田 正 and 生水 真紀夫},
 month = {Jun},
 note = {Aim: To evaluate the toxicity and efficacy of carbon ion radiotherapy (C-ion RT) for locally advanced adenocarcinoma of the uterine cervix in phase I / II clinical trials.
Method: The treatment consisted of whole pelvic irradiation of 36.0 gray equivalents (GyE) with 12 fractions and extended local boost with dose escalation from 26.4GyE to 38.4GyE in 8 fractions with 2.4 or 3.6 GyE increments of fraction dose. The dose escalation was performed with careful observation of acute normal tissue responses. Total dose to the cervical tumor was 62.4 – 74.4 GyE for 20 fractions. 
Results: Between April 1998 and February 2010, 58 patients were treated with C-ion RT in this clinical trial. The number of patients with stage IIB, IIIB, and IVA disease were 20, 35, and 3, respectively. Median tumor size was 5.5 cm (range, 3.0-11.8 cm). Histologically, 48 patients had adenocarcinoma and 10 patients had adenosquamous cell carcinoma. Twenty-seven patients had pelvic lymph node metastases. The median follow-up period for surviving and all patients were 66 and 37 months, respectively. Although 23 patients developed acute toxicity (G1-G2), all patients completed the treatment on schedule. Late toxicity was found in 19 patients whose toxicity observed was G1 or G2 except one with G4: G2 toxicity was detected 7 patients (12 %): 5 patients for bladder and 2 patients for small intestine. One patient had G4 rectal complication, which was surgically salvaged. Twenty-two patients (37.9 %) had local recurrence, 9 of which received salvage surgery and 37 patients (63.8%) had distant metastases. The 3-year local control rate, local control rate including salvage surgery and overall survival rate were 59.0 %, 72.3 % and 53.2 %, respectively. 
Conclusions; Carbone-ion RT for adenocarcinoma of the uterine cervix was a safe treatment. Although the number of patients in this study was small, the results support continued investigation to confirm therapeutic efficacy., 52nd Annual Conference of the Particle Therapy Co-Operative Group（PTCOG52）},
 title = {Carbon ion Radiotherapy for locally advanced adenocarcinoma of the uterine cervix},
 year = {2013}
}