@misc{oai:repo.qst.go.jp:00065027,
 author = {Hasegawa, Sumitaka and 長谷川 純崇},
 month = {May},
 note = {Multimodal molecular/cellular imaging using magnetic resonance imaging (MRI) and optical imaging has been actively investigated and made a rapid progress in the past decade. These techniques have been shown to contribute to a wide range of cancer research, for example, the development of early diagnosis of cancer and the assessment of therapeutic efficacy. In this symposium, I would like to present our recent progress in multimodal imaging using MRI and optical imaging; noninvasive monitoring of intratumoral transgene expression for gene therapy and targeted detection of mesothelioma based on the biological characteristics of the tumor cells. 
We developed a method for monitoring in vivo transgene expression mediated by electroporation (EP) in a tumor model. EP has been used in the laboratory for gene delivery to cells in vitro or in vivo, and is recently receiving much attention in clinical cancer gene therapy. Using ferritin MR transgene reporter coupled with an optical gene reporter, we visualized intratumoral transgene expression by MRI and optical imaging. 
We also developed a method for targeted detection of mesothelioma by manganese-enhanced MRI (MEMRI). Mesothelioma is mainly caused by exposure to asbestos and is one of the intractable cancers because of the difficulty in early diagnosis and resistance to conventional therapy. Manganese-superoxide dismutase, an antioxidant enzyme cofactored with manganese, is overexpressed in mesothelioma and is therefore an attractive target for mesothelioma detection. We applied MEMRI and in vivo fluorescence imaging to detect mesothelioma stably expressing fluorescence protein in a preclinical animal model. Our study suggested that MEMRI represents a promising approach for a more selective mesothelioma imaging., 第8回日本分子イメージング学会総会・学術集会},
 title = {Multimodal approach for cancer research using MRI and optical imaging},
 year = {2013}
}