@misc{oai:repo.qst.go.jp:00065009,
 author = {Sasahara, Go and Ikawa, Hiroaki and Takagi, Ryo and Koto, Masashi and Hasegawa, Azusa and Tsuji, Hiroshi and Kamada, Tadashi and Okamoto, Yoshitaka and 佐々原 剛 and 伊川 裕明 and 高木 亮 and 小藤 昌志 and 長谷川 安都佐 and 辻 比呂志 and 鎌田 正 and 岡本 美孝},
 month = {May},
 note = {Purpose: The purpose of this study is to analyze the relation between the irradiation dose of maxilla and osteoradionecrosis after carbon ion radiotherapy using dose-volume histograms.
Materials and Methods: From April 1997 to April 2006, 243 patients with tumors in the head and neck region were treated with carbon ion radiotherapy in our institution. Analysis was performed to 59 patients whose alveolar process and palatine process of maxilla had been included in the irradiated volume and had not been infiltrated by the tumor. These patients had a follow-up period of at least 2 years.
We evaluated the prognostic factors of osteoradionecrosis in carbon ion radiotherapy, using dose-volume histograms.
Results: The median age of 59 patients (31 men, 28 women) was 58 years. The prescribed tumor dose was 57.6 GyE in 16 fractions over 4 weeks. Dose-volume histogram analysis revealed that the percentages of maxilla volume receiving more than 50 GyE (V50) were significantly higher in patients with >grade 1 osteonecrosis than in those with grade 0. The number of teeth within radiation fields and were correlated with osteoradionecrosis.
Conclusions: V50 and the number of teeth within radiation fields were significant risk factors for >grade 1 osteoradionecrosis induced by carbon ion radiotherapy administered in 16 fractions., Heavy Ion in Therapy and Space Radiation Symposium 2013(HITSRS2013)},
 title = {Correlation of Obsteoradionecrosis with Dosimetric Parameters in Carbon Ion Radiotherapy},
 year = {2013}
}