{"created":"2023-05-15T14:47:24.509262+00:00","id":65006,"links":{},"metadata":{"_buckets":{"deposit":"ca74fe8c-00ae-4303-9bdc-7a783542ba6f"},"_deposit":{"created_by":1,"id":"65006","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"65006"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00065006","sets":["10:29"]},"author_link":["640541","640543","640544","640545","640546","640542","640548","640547"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2013-05-18","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"From 1994 to 1999, we conducted a phase I/II clinical trial for stage I non-small cell lung cancer (NSCLC) by using carbon ion beams alone, demonstrating optimal doses of 90.0GyE in 18 fractions over 6 weeks (Protocol #9303) and 72.0GyE in 9 fractions over 3 weeks ( #9701) for achieving more than 95% local control with minimal pulmonary damage. In the present study, the total dose was fixed at 72.0GyE in 9 fractions over 3 weeks (#9802), and at 52.8GyE for stage IA and 60.0GyE for stage 1B in 4 fractions in 1 week (#0001). Following this schedule, we conducted a phase II clinical trial for stage I NSCLC from 1999 to 2003. We also conducted a phase I/II single fractionation clinical trial (#0201), a dose escalation study. The total dose was initially 28.0GyE in 2003, and it was raised to 50.0GyE in 2011. \nThe local control rate for all patients (#9802 and #0001) was 91.5%, and those for T1 and T2 tumors were 96.3% and 84.7%, respectively. The 5-year cause-specific survival rate was 67.0% (IA: 84.4, IB: 43.7), and overall survival was 45.3% (IA: 53.9, 1B: 34.2). No adverse effects greater than grade 2 occurred in the lung. \nIn a single fractionation trial, the 5-year local control rate for 151 patients was 79.2%, and the control rates for T1 and T2 tumors were 83.6% and 72.2%, respectively. No adverse effects greater than grade 2 occurred in the lung. \nCarbon beam radiotherapy, an excellent new modality in terms of high QOL and ADL, was proven to be a valid alternative to surgery for stage I cancer, especially for elderly and inoperable patients.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"Heavy Ion in Therapy and Space Radiation Symposium 2013(HITSRS2013)","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Takahashi, Wataru"}],"nameIdentifiers":[{"nameIdentifier":"640541","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamamoto, Naoyoshi"}],"nameIdentifiers":[{"nameIdentifier":"640542","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakajima, Mio"}],"nameIdentifiers":[{"nameIdentifier":"640543","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kamada, Tadashi"}],"nameIdentifiers":[{"nameIdentifier":"640544","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高橋 渉","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"640545","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山本 直敬","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"640546","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中嶋 美緒","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"640547","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鎌田 正","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"640548","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Carbon Ion Radiotherapy in a Hypo-fractionation Regimen for Stage I Non-SmallCell Lung Cancer","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Carbon Ion Radiotherapy in a Hypo-fractionation Regimen for Stage I Non-SmallCell Lung Cancer"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-05-23"},"publish_date":"2013-05-23","publish_status":"0","recid":"65006","relation_version_is_last":true,"title":["Carbon Ion Radiotherapy in a Hypo-fractionation Regimen for Stage I Non-SmallCell Lung Cancer"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:05:07.612120+00:00"}