{"created":"2023-05-15T14:47:16.851036+00:00","id":64836,"links":{},"metadata":{"_buckets":{"deposit":"4c44afcd-76ce-42ee-b1ac-ed7d320b6f67"},"_deposit":{"created_by":1,"id":"64836","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"64836"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00064836","sets":["10:29"]},"author_link":["638947","638937","638939","638935","638936","638945","638941","638944","638948","638938","638940","638934","638946","638949","638943","638942"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2012-10-13","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【目的】MRIで測定した黒質の神経メラニンと、PETで測定したドパミントランスポー\nター(DAT)における加齢の影響調べる。【対象および方法】若年健常者7例（23±2歳\n）と高齢健常者5例(67±7歳)を対象とし、 3テスラMRIでT1強調FSEにて, 第4脳室底\nに垂直に脳幹の14スライス（2.5mm厚）を撮像した。円形の関心領域を上小脳脚交差\n部(DS)と黒質(SN)に置き、両部位の信号比[(S<SUB>SN</SUB>-S<SUB>DS</SUB>)/S<SUB\n>DS</SUB>*100]を求めて神経メラニンの指標とした。[<SUP>18</SUP>F]PE2Iを静脈投\n与し、PETにて90分間ダイナミック撮像した。小脳皮質を参照領域としてSimplified\nreference tissue model解析して被殻の結合能を求めた。【結果】黒質の神経メラニ\nンの信号比は若年健常者で24.0±2.7、高齢健常者で26.9±2.4で、高齢健常者で高い\n傾向がみられた（p ＜ 0.09）。一方、被殻のDAT結合能は若年健常者で4.19±0.50、\n高齢健常者で2.26±0.43であり、高齢健常者で低下していた（p ＜ 0.0001）。【結\n論】黒質線条体ニューロンは加齢とともに神経メラニンの含有量が増加し、一方、機\n能は低下すると考えられた。　","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第52回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"篠遠, 仁"}],"nameIdentifiers":[{"nameIdentifier":"638934","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田, 斉"}],"nameIdentifiers":[{"nameIdentifier":"638935","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"平野, 成樹"}],"nameIdentifiers":[{"nameIdentifier":"638936","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鈴木, 雅之"}],"nameIdentifiers":[{"nameIdentifier":"638937","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"森, 崇明"}],"nameIdentifiers":[{"nameIdentifier":"638938","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"川口, 拓之"}],"nameIdentifiers":[{"nameIdentifier":"638939","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤, 浩"}],"nameIdentifiers":[{"nameIdentifier":"638940","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原, 哲也"}],"nameIdentifiers":[{"nameIdentifier":"638941","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"篠遠 仁","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"638942","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田 斉","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"638943","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"平野 成樹","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"638944","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鈴木 雅之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"638945","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"森 崇明","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"638946","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"川口 拓之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"638947","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤 浩","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"638948","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原 哲也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"638949","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"黒質の神経メラニンと被殻のドパミントランスポーターにおける加齢の影響","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"黒質の神経メラニンと被殻のドパミントランスポーターにおける加齢の影響"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-11-15"},"publish_date":"2012-11-15","publish_status":"0","recid":"64836","relation_version_is_last":true,"title":["黒質の神経メラニンと被殻のドパミントランスポーターにおける加齢の影響"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:07:03.639436+00:00"}