{"created":"2023-05-15T14:47:15.432980+00:00","id":64804,"links":{},"metadata":{"_buckets":{"deposit":"fb6a448b-2f4c-41a3-b70a-63f3e2eb76bb"},"_deposit":{"created_by":1,"id":"64804","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"64804"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00064804","sets":["10:29"]},"author_link":["638516","638517","638514","638513","638512","638515","638519","638518","638520"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2012-10-13","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"我々はこれまで、癌細胞株のマウス移植腫瘍において低酸素組織に集積するCu -ATSMと低酸素状態で亢進する糖代謝を反映するFDGの分布が大きく異なることを報告してきた。一方臨床では、SCCでは両者の腫瘍内分布に負の相関が、腺癌では正の相関が見られたとの報告がある。このような集積パターンの乖離が組織型に依存した腫瘍内の微小環境や癌細胞の性質を反映するのか、細胞株移植腫瘍の特殊性などに起因する“artifact”なのかに興味が持たれた。今回ヒトの病理組織像をよく再現する腺癌由来のCTOS（Cancer Tissue Originated Spheroid）移植腫瘍を使用する機会を得、64Cu-ATSMと14C-FDGの腫瘍内分布を比較した。全般に両者の集積が重なる部分が多いものの細部では不一致も認められ、結節によっては細胞株移植腫瘍に近いパターンも観察された。今回の検討より、CTOS腫瘍のモデルとしての優位性とともに両薬剤の腫瘍内分布が臨床例においても細部では異なる可能性が示唆された。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第52回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"古川, 高子"}],"nameIdentifiers":[{"nameIdentifier":"638512","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉井, 幸恵"}],"nameIdentifiers":[{"nameIdentifier":"638513","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤林, 康久"}],"nameIdentifiers":[{"nameIdentifier":"638514","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐賀, 恒夫"}],"nameIdentifiers":[{"nameIdentifier":"638515","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"その他"}],"nameIdentifiers":[{"nameIdentifier":"638516","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古川 高子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"638517","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉井 幸恵","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"638518","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤林 康久","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"638519","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐賀 恒夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"638520","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"ヒトの病理組織像を再現するCTOS移植腫瘍におけるCu-ATSMとFDGの結節内分布","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ヒトの病理組織像を再現するCTOS移植腫瘍におけるCu-ATSMとFDGの結節内分布"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-10-19"},"publish_date":"2012-10-19","publish_status":"0","recid":"64804","relation_version_is_last":true,"title":["ヒトの病理組織像を再現するCTOS移植腫瘍におけるCu-ATSMとFDGの結節内分布"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:07:26.768490+00:00"}