{"created":"2023-05-15T14:47:15.214393+00:00","id":64799,"links":{},"metadata":{"_buckets":{"deposit":"7dc17cc1-06f1-4b7d-ba76-f0cd6b741ad1"},"_deposit":{"created_by":1,"id":"64799","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"64799"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00064799","sets":["10:29"]},"author_link":["638474","638469","638476","638471","638473","638479","638478","638481","638470","638475","638472","638480","638482","638477"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2012-10-13","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Translocator protein (18kDa) (TSPO) plays important roles in cell proliferation and cancer progress. Here, we explored the feasibility of TSPO as an imaging biomarker in the detection of hepatocellular carcinoma (HCC) that could be monitored using PET with a TSPO radioligand [18F]FEDAC. Cell binding assay and PET/CT with [18F]FEDAC quantified TSPO in HCC cell lines differing in their invasive and chemotactic potential and orthotopic HCC. Uptake of [18F]FEDAC was increased in the highly aggressive cell lines HLE (12.07 +/- 0.96 %ICD/mg protein), relative to nonaggressive cell line HepG2 (3.87 +/- 0.36 %ICD/mg protein). Uptake of radioactivity was 3.71 fold in the livers of orthotopic HCC compared with the control mice ( p<0.05 ). Conclusions: TSPO expression increases in HCC and closely correlates with HCC aggressive phenotype expression. Further, the change of TSPO can be sensitively monitored by TSPO-PET.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第52回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"謝, 琳"}],"nameIdentifiers":[{"nameIdentifier":"638469","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"由井, 譲二"}],"nameIdentifiers":[{"nameIdentifier":"638470","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"羽鳥, 晶子"}],"nameIdentifiers":[{"nameIdentifier":"638471","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山崎, 友照"}],"nameIdentifiers":[{"nameIdentifier":"638472","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"熊田, 勝志"}],"nameIdentifiers":[{"nameIdentifier":"638473","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"脇坂, 秀克"}],"nameIdentifiers":[{"nameIdentifier":"638474","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張, 明栄"}],"nameIdentifiers":[{"nameIdentifier":"638475","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"謝 琳","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"638476","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"由井 譲二","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"638477","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"羽鳥 晶子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"638478","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山崎 友照","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"638479","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"熊田 勝志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"638480","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"脇坂 秀克","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"638481","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"638482","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"TSPOを標的とした肝細胞癌の画像診断法の開発に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"TSPOを標的とした肝細胞癌の画像診断法の開発に関する研究"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-10-17"},"publish_date":"2012-10-17","publish_status":"0","recid":"64799","relation_version_is_last":true,"title":["TSPOを標的とした肝細胞癌の画像診断法の開発に関する研究"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:07:30.180782+00:00"}