@misc{oai:repo.qst.go.jp:00064799,
 author = {謝, 琳 and 由井, 譲二 and 羽鳥, 晶子 and 山崎, 友照 and 熊田, 勝志 and 脇坂, 秀克 and 張, 明栄 and 謝 琳 and 由井 譲二 and 羽鳥 晶子 and 山崎 友照 and 熊田 勝志 and 脇坂 秀克 and 張 明栄},
 month = {Oct},
 note = {Translocator protein (18kDa) (TSPO) plays important roles in cell proliferation and cancer progress. Here, we explored the feasibility of TSPO as an imaging biomarker in the detection of hepatocellular carcinoma (HCC) that could be monitored using PET with a TSPO radioligand [18F]FEDAC. Cell binding assay and PET/CT with [18F]FEDAC quantified TSPO in HCC cell lines differing in their invasive and chemotactic potential and orthotopic HCC. Uptake of [18F]FEDAC was increased in the highly aggressive cell lines HLE (12.07 +/- 0.96 %ICD/mg protein), relative to nonaggressive cell line HepG2 (3.87 +/- 0.36 %ICD/mg protein). Uptake of radioactivity was 3.71 fold in the livers of orthotopic HCC compared with the control mice ( p<0.05 ). Conclusions: TSPO expression increases in HCC and closely correlates with HCC aggressive phenotype expression. Further, the change of TSPO can be sensitively monitored by TSPO-PET., 第52回日本核医学会学術総会},
 title = {TSPOを標的とした肝細胞癌の画像診断法の開発に関する研究},
 year = {2012}
}