{"created":"2023-05-15T14:47:15.170374+00:00","id":64798,"links":{},"metadata":{"_buckets":{"deposit":"af6508f0-9ed8-4669-9625-d2b0da5a8662"},"_deposit":{"created_by":1,"id":"64798","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"64798"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00064798","sets":["10:29"]},"author_link":["638462","638456","638463","638464","638465","638461","638467","638460","638453","638457","638468","638455","638466","638458","638454","638459"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2012-10-13","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"脂肪酸合成酵素（Fatty acid synthase, FASN）は、多種のがんにおいて発現が亢進し、予後不良に関係している。一方近年、FASN阻害剤（Orlistat）に抗腫瘍効果があることが報告され注目を集めている。しかし、FASN発現量は個々の腫瘍により大きく異なるため、FASN標的治療を行うためには、FASN発現量を事前に評価し、治療効果を予測する必要がある。本研究では、[1-11C]酢酸PETのFASN標的治療事前効果予測における有用性を評価する目的で、ヒト前立腺がん細胞を用い、酢酸取込とFASN発現・FASN標的治療の治療効果との関係につき、in vitro並びにin vivoで調査した。その結果、細胞の酢酸取込量はFASN発現量並びにOrlistat治療効果と正の相関関係にあること、酢酸PETはOrlistat治療効果の高い腫瘍を検出できることが示された。以上から、酢酸PETはFASN標的治療における事前効果予測に有用であり、がん個別化医療を行う上で重要なツールになると考えられた。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第52回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"吉井, 幸恵"}],"nameIdentifiers":[{"nameIdentifier":"638453","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古川, 高子"}],"nameIdentifiers":[{"nameIdentifier":"638454","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"清野, 泰"}],"nameIdentifiers":[{"nameIdentifier":"638455","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"西井, 龍一"}],"nameIdentifiers":[{"nameIdentifier":"638456","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻, 厚至"}],"nameIdentifiers":[{"nameIdentifier":"638457","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"脇坂, 秀克"}],"nameIdentifiers":[{"nameIdentifier":"638458","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤林, 康久"}],"nameIdentifiers":[{"nameIdentifier":"638459","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐賀, 恒夫"}],"nameIdentifiers":[{"nameIdentifier":"638460","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"その他"}],"nameIdentifiers":[{"nameIdentifier":"638461","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉井 幸恵","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"638462","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古川 高子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"638463","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"西井 龍一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"638464","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻 厚至","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"638465","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"脇坂 秀克","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"638466","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤林 康久","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"638467","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐賀 恒夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"638468","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"［ 1-11C］酢酸PETによる脂肪酸合成酵素標的がん制御治療の効果予測","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"［ 1-11C］酢酸PETによる脂肪酸合成酵素標的がん制御治療の効果予測"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-10-17"},"publish_date":"2012-10-17","publish_status":"0","recid":"64798","relation_version_is_last":true,"title":["［ 1-11C］酢酸PETによる脂肪酸合成酵素標的がん制御治療の効果予測"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:07:30.877826+00:00"}