{"created":"2023-05-15T14:47:14.993964+00:00","id":64794,"links":{},"metadata":{"_buckets":{"deposit":"45fd71b0-7478-4187-803a-a81d546f9ce6"},"_deposit":{"created_by":1,"id":"64794","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"64794"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00064794","sets":["10:29"]},"author_link":["638392","638391","638390","638394","638396","638389","638395","638393"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2012-10-13","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【目的】近年、[11C]COCl2などの標識中間体が簡便にかつ高い再現性で調製でき、それらを利用したPETプローブが報告されている。一方、[11C]CH2Oも有効な標識中間体として考えられるが、それを利用したPETプローブの合成例は少ない。今回 [11C]CH2Oを用いて種々のTrp誘導体との間のピクテ-スペングラー反応を試み、[11C]-1,2,3,4-テトラヒドロ--カルボリン誘導体の合成条件を精査した。【方法・結論】 [11C]CH2O は[11C]CH3Iとトリメチルアミン-N-オキシドのDMF溶液との反応により調製した。反応基質として計9種類のTrp誘導体を用い、酸触媒は計3種類を用いた。種々のTrp誘導体（6種類）は[11C]CH2Oから中程度の転換率(40-50%)で目的物が得られたのに対して、インドール環に電子吸引基をもつTrp誘導体は目的物が得られない。[11C]CH2Oを用いたピクテ-スペングラー反応はインドール環のπ電子密度が重要な因子であることがわかった。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第52回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"破入, 正行"}],"nameIdentifiers":[{"nameIdentifier":"638389","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"橋本, 裕輝"}],"nameIdentifiers":[{"nameIdentifier":"638390","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"河村, 和紀"}],"nameIdentifiers":[{"nameIdentifier":"638391","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"福村, 利光"}],"nameIdentifiers":[{"nameIdentifier":"638392","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"破入 正行","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"638393","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"橋本 裕輝","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"638394","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"河村 和紀","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"638395","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"福村 利光","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"638396","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"ピクテ-スペングラー反応を用いた[11C]-テトラヒドロカルボリン誘導体の合成","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ピクテ-スペングラー反応を用いた[11C]-テトラヒドロカルボリン誘導体の合成"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-10-16"},"publish_date":"2012-10-16","publish_status":"0","recid":"64794","relation_version_is_last":true,"title":["ピクテ-スペングラー反応を用いた[11C]-テトラヒドロカルボリン誘導体の合成"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:07:33.638690+00:00"}