{"created":"2023-05-15T14:47:14.949888+00:00","id":64793,"links":{},"metadata":{"_buckets":{"deposit":"9276f0e6-4b78-4ce7-a8c9-3517ffb491ff"},"_deposit":{"created_by":1,"id":"64793","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"64793"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00064793","sets":["10:29"]},"author_link":["638386","638381","638383","638379","638378","638375","638384","638387","638376","638385","638382","638388","638380","638377"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2012-10-13","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"PETによる血液脳関門（BBB）の機能評価は、中枢神経疾患の診断・治療や、薬物輸送研究に大きく貢献すると考えられる。2-アミノイソ酪酸（AIB）は、BBBにほとんど存在しないシステムA輸送体で主に膜輸送されるため、通常ではBBB透過性が極めて低い。一方、BBBの異常等で脳へ流入した場合には脳組織で留まるため、AIBはBBBの機能評価に有用であると考えられる。そこで本研究では[3-11C]AIBのPET撮像を行い従来のBBB機能評価法と比較検討した。\nリポ多糖等の薬物で片側線条体のBBBを局所的に破壊したラットを用いて[3-11C]AIBのPET撮像を行ったところ、対照側に比べてBBB破壊側の放射能集積は有意に高かった。また同一個体のex vivo脳切片における[14C]スクロースおよびエバンスブルーと[3-11C]AIBの集積をARG/蛍光染色法で比較したところ、[3-11C]AIBの集積領域は[14C]スクロースおよびエバンスブルーと一致していたが、対照側との比や再現性は[3-11C]AIBが従来法に比べて優れていた。\n以上の結果から、[3-11C]AIBはPETによるBBBの機能評価に有用であることが示された。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第52回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"岡田, 真希"}],"nameIdentifiers":[{"nameIdentifier":"638375","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻, 厚至"}],"nameIdentifiers":[{"nameIdentifier":"638376","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"菊池, 達矢"}],"nameIdentifiers":[{"nameIdentifier":"638377","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"脇坂, 秀克"}],"nameIdentifiers":[{"nameIdentifier":"638378","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岡村, 敏充"}],"nameIdentifiers":[{"nameIdentifier":"638379","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張, 明栄"}],"nameIdentifiers":[{"nameIdentifier":"638380","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"加藤, 孝一"}],"nameIdentifiers":[{"nameIdentifier":"638381","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岡田 真希","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"638382","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻 厚至","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"638383","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"菊池 達矢","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"638384","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"脇坂 秀克","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"638385","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岡村 敏充","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"638386","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"638387","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"加藤 孝一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"638388","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"2-Amino-[3-11C]isobutyric acidによる血液脳関門の高感度PETイメージング","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"2-Amino-[3-11C]isobutyric acidによる血液脳関門の高感度PETイメージング"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-10-16"},"publish_date":"2012-10-16","publish_status":"0","recid":"64793","relation_version_is_last":true,"title":["2-Amino-[3-11C]isobutyric acidによる血液脳関門の高感度PETイメージング"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:07:34.312023+00:00"}