{"created":"2023-05-15T14:47:14.862688+00:00","id":64791,"links":{},"metadata":{"_buckets":{"deposit":"9ac587be-d9ed-4c5d-8957-620560ebbb2d"},"_deposit":{"created_by":1,"id":"64791","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"64791"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00064791","sets":["10:29"]},"author_link":["638357","638343","638352","638350","638349","638351","638356","638348","638355","638340","638346","638342","638354","638345","638353","638341","638347","638344"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2012-10-13","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"目的：持続的低酸素暴露による糖トランスポータGLUT1の発現の上昇を検証するため、低酸素濃度で1〜4週間飼育のマウスと正常酸素濃度飼育マウスでFDG初期Patlak勾配とCMRGlcを求めた。方法：尾静脈確保後1.0〜1.2％イソフレラン麻酔下で体温管理し、2匹ずつ動物用PET(Inveon)に固定しFDG約200〜300muCiをポンプで30秒間定速静注し60分間ダイナミック収集した。スキャン終了直後に心腔から100muLの動脈血を採血し全血放射能濃度と血糖値を測定した。測定データはPMODでROI設定と解析を行った。GLUT1発現によるK1上昇を反映する指標として心腔大動脈ROIを入力関数とする初期2分間のPatlakプロット勾配からK1指標を求めた。また、後採血放射能濃度で校正した肝臓領域ROIを入力関数としてCMRGlcを3コンパートメントモデルで計算した。結果と考察：CMRGlcは低酸素暴露群で正常酸素群に比べ有意な変化はなかったが、K1指標は低酸素暴露群で優位に高値を示した。これは低酸素暴露により脳内GLUT1発現が上昇し糖トランスポータの機能が亢進した結果であることを示唆する。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第52回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"菅野, 巖"}],"nameIdentifiers":[{"nameIdentifier":"638340","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田桑, 弘之"}],"nameIdentifiers":[{"nameIdentifier":"638341","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"関, 千江"}],"nameIdentifiers":[{"nameIdentifier":"638342","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"正本, 和人"}],"nameIdentifiers":[{"nameIdentifier":"638343","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"谷口, 順子"}],"nameIdentifiers":[{"nameIdentifier":"638344","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"川口, 拓之"}],"nameIdentifiers":[{"nameIdentifier":"638345","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"生駒, 洋子"}],"nameIdentifiers":[{"nameIdentifier":"638346","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"脇坂, 秀克"}],"nameIdentifiers":[{"nameIdentifier":"638347","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤, 浩"}],"nameIdentifiers":[{"nameIdentifier":"638348","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"菅野 巖","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"638349","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田桑 弘之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"638350","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"関 千江","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"638351","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"正本 和人","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"638352","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"谷口 順子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"638353","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"川口 拓之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"638354","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"生駒 洋子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"638355","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"脇坂 秀克","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"638356","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤 浩","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"638357","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"持続的低酸素暴露マウスの脳におけるFDG測定","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"持続的低酸素暴露マウスの脳におけるFDG測定"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-10-15"},"publish_date":"2012-10-15","publish_status":"0","recid":"64791","relation_version_is_last":true,"title":["持続的低酸素暴露マウスの脳におけるFDG測定"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:07:35.680367+00:00"}