{"created":"2023-05-15T14:47:14.510673+00:00","id":64783,"links":{},"metadata":{"_buckets":{"deposit":"9033d1e8-e901-4a7e-98d6-29f49121f31a"},"_deposit":{"created_by":1,"id":"64783","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"64783"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00064783","sets":["10:29"]},"author_link":["638273","638276","638268","638265","638272","638266","638267","638274","638271","638264","638270","638269","638263","638275"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2012-10-13","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【目的】ヒト黒質のドーパミン作動性神経において産生されるニューロメラニン(NM)\nの濃度とこのニューロンに発現しているドーパミントランスポーター(DAT)の分布密\n度をそれぞれMRIとPETにより計測し、両者の関連を検討した。【方法】健常ボランテ\nィア4名およびパーキンソン病患者5名を対象に、MRIによるNM画像の撮像と[<sup>18<\n/sup>F]FE-PE2IによるダイナミックPET測定を施行した。PETデータから参照領域法に\nよりDAT結合能画像(BP<SUB>ND</SUB>画像)を求めた。BP<SUB>ND</SUB>画像とNM画像\nは解剖学的に標準化し、全被験者の平均画像上で黒質の関心領域を決めた。NM濃度の\n指標(NM値)は黒質と小脳脚交差部の信号比とした。【結果と考察】PD患者ではNM値と\nBP<SUB>ND</SUB>値の両方が低値であったが、健常人では少なくとも一方が高値を示\nした。このことから、同一人のNM値とBP<SUB>ND</SUB>値を測ることでPDの診断能の\n向上が期待できる。NM値とBP<SUB>ND</SUB>値の相関係数は健常群、患者群、全被験\n者のそれぞれで-0.53, 0.23, 0.28であり、統計的有意ではなかった。NM値はBP<SUB>\nND</SUB>値が示す神経機能の付加的な情報となりうることが示唆された。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第52回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"川口, 拓之"}],"nameIdentifiers":[{"nameIdentifier":"638263","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田, 斉"}],"nameIdentifiers":[{"nameIdentifier":"638264","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"篠遠, 仁"}],"nameIdentifiers":[{"nameIdentifier":"638265","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"平野, 成樹"}],"nameIdentifiers":[{"nameIdentifier":"638266","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ｋｅｒｓｈａｗ, Ｊｅｆｆｒｅｙ"}],"nameIdentifiers":[{"nameIdentifier":"638267","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原, 哲也"}],"nameIdentifiers":[{"nameIdentifier":"638268","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤, 浩"}],"nameIdentifiers":[{"nameIdentifier":"638269","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"川口 拓之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"638270","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田 斉","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"638271","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"篠遠 仁","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"638272","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"平野 成樹","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"638273","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ｋｅｒｓｈａｗ Ｊｅｆｆｒｅｙ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"638274","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原 哲也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"638275","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤 浩","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"638276","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"ヒト黒質におけるニューロメラニンMRIとドーパミントランスポーター分布密度の比較","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ヒト黒質におけるニューロメラニンMRIとドーパミントランスポーター分布密度の比較"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-10-15"},"publish_date":"2012-10-15","publish_status":"0","recid":"64783","relation_version_is_last":true,"title":["ヒト黒質におけるニューロメラニンMRIとドーパミントランスポーター分布密度の比較"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:07:41.018736+00:00"}