{"created":"2023-05-15T14:47:11.627475+00:00","id":64718,"links":{},"metadata":{"_buckets":{"deposit":"11b76acb-3383-4302-809f-383a390393b6"},"_deposit":{"created_by":1,"id":"64718","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"64718"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00064718","sets":["10:29"]},"author_link":["637705","637709","637708","637693","637698","637690","637699","637686","637702","637685","637682","637689","637687","637697","637695","637694","637696","637683","637684","637692","637688","637706","637704","637703","637700","637701","637691","637707"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2012-09-08","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【目的】ヒト黒質のドーパミン作動性神経系ニューロンにおいて産生されるニューロメラニン(NM)の濃度とこのニューロンに発現しているドーパミントランスポーター(DAT)の分布密度をそれぞれMRIとPETにより計測し、両者の関連を検討した。【方法】健常ボランティア7名(67.4 ± 7.0 yo)およびパーキンソン病患者5名(69.6 ± 5.1 yo)に対して、MRIによるNM画像の撮像と[18F]FE-PE2Iによる90分間のダイナミックPET測定を施行した。PET画像から参照領域法によりDAT結合能画像(BPND画像)を求めた。BPND画像とNM画像は解剖学的に標準化した。関心領域はNM原画像上で設定したものを解剖学的標準化し、健常人のものを平均化した画像を用いて決定した。NM濃度の指標(NM値)は黒質と小脳脚交差部の信号比とした。【結果と考察】図に示すようにPD患者ではNM値とBPND値の両方が低値であったが、健常人(NV)では少なくとも一方が高値を示した。このことから、同一人のNM値とBPND値を測ることでPDの診断能の向上が期待できる。NM値とBPND値の相関係数は健常群、患者群、全被験者のそれぞれで-0.13, -0.46, 0.34であり、統計的有意ではなかった。このことから、NM値はBPND値が示すニューロン機能の付加的な情報となりうることが示唆された。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第40回日本磁気共鳴医学会大会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"川口, 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千江"}],"nameIdentifiers":[{"nameIdentifier":"637690","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"木村, 泰之"}],"nameIdentifiers":[{"nameIdentifier":"637691","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小高, 文聰"}],"nameIdentifiers":[{"nameIdentifier":"637692","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"菅野, 巖"}],"nameIdentifiers":[{"nameIdentifier":"637693","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原, 哲也"}],"nameIdentifiers":[{"nameIdentifier":"637694","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤, 浩"}],"nameIdentifiers":[{"nameIdentifier":"637695","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"川口 拓之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"637696","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田 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